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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 183 - 194 (12page)
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초록· 키워드
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Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. Although advances have been made in the treatment of MS, such as the use of IFN-b, glucocorticoids and stem cells, the therapeutic effects of these treatments are not sufficient. In the present study, we evaluated whether the combination of methyl- prednisolone (MP) and human bone marrow-derived mesenchymal stem cells (BM-MSCs) could enhance the therapeutic effectiveness in experimental autoimmune encephalomyelitis (EAE), a model for MS. EAE was induced by immunizing C57BL/6 mice with myelin oligodendrocyte glycoprotein 35-55 (MOG 35-55). The immunized mice received an intraperitoneal injection of MP (20 mg/kg), an intravenous injection of BM-MSCs (1 9 10 6 cells) or both on day 14 after immunization. Combination treatment significantly ameliorated the clinical symptoms, along with attenuating inflamma- tory infiltration and demyelination, compared to either treatment alone. Secretion of pro-inflammatory cytokines (IFN-c, TNF-a, IL-17) was significantly reduced, and anti-inflammatory cytokines (IL-4, IL-10) was significantly increased by the combination treatment as compared to either treatment alone. Flow cytometry analysis of MOG-reactivated T cells in spleen showed that combination treatment reduced the number of CD4? CD45? and CD8? T cells, and increased the number of CD4? CD25? Foxp3? regulatory T cells. Furthermore, combination treatment enhanced apoptosis in MOG- reactivated CD4? T cells, a key cellular subset in MS pathogenesis. Combination treatment with MP and BM-MSCs provides a novel treatment protocol for enhancing therapeutic effects in MS.
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등록된 정보가 없습니다.
참고문헌 (57)
참고문헌 신청
El Behi M / 2005 / New insights into cell responses involved in experimental autoimmune encephalomyelitis and multiple sclerosis / Immunol Lett 96:11~26
Reichardt HM / 2006 / Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis / Expert Rev Neurother 6:1657~1670
Sospedra M / 2005 / Antigen-specific therapies in multiple sclerosis / Int Rev Immunol 24:393~413
Hedegaard CJ / 2008 / T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis / Immunology 125:161~169
Pfeiffer F / 2011 / Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis / Acta Neuropathol 122:601~614
Reichardt HM / 2006 / Glucocorticoids in multiple sclerosis and experimental autoimmune encephalomyelitis / Expert Rev Neurother 6:1657~1670
Sospedra M / 2005 / Antigen-specific therapies in multiple sclerosis / Int Rev Immunol 24:393~413
Hedegaard CJ / 2008 / T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis / Immunology 125:161~169
Pfeiffer F / 2011 / Claudin-1 induced sealing of blood-brain barrier tight junctions ameliorates chronic experimental autoimmune encephalomyelitis / Acta Neuropathol 122:601~614
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