Current Status of Stem Cell Treatment for Type I Diabetes Mellitus

Anupama Kakkar; Ashima Sorout; Mahak Tiwari; Pallavi Shrivastava; Poonam Meena; Sumit Kumar Saraswat; Supriya Srivastava; Rajan Datt; Siddharth Pandey

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자료유형: 학술저널

저자정보: Anupama Kakkar (Datt Mediproducts Pvt Ltd) Ashima Sorout (Datt Mediproducts Pvt Ltd) Mahak Tiwari (Datt Mediproducts Pvt Ltd) Pallavi Shrivastava (Datt Mediproducts Pvt Ltd) Poonam Meena (Datt Mediproducts Pvt Ltd) Sumit Kumar Saraswat (Datt Mediproducts Pvt Ltd) Supriya Srivastava (Datt Mediproducts Pvt Ltd) Rajan Datt (Datt Mediproducts Pvt Ltd) Siddharth Pandey (Datt Mediproducts Pvt)

저널정보: 한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제15권 제6호

발행연도: 2018.1

수록면: 699 - 709 (11page)

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BACKGROUND: Diabetes mellitus is a major health concern in current scenario which has been found to affect people of almost all ages. The disease has huge impact on global health; therefore, alternate methods apart from insulin injection are being explored to cure diabetes. Therefore, this review mainly focuses on the current status and therapeutic potential of stem cells mainly mesenchymal stem cells (MSCs) for Type 1 diabetes mellitus in preclinical animal models as well as humans. METHODS: Current treatment for Type 1 diabetes mellitus mainly includes use of insulin which has its own limitations and also the underlying mechanism of diseases is still not explored. Therefore, alternate methods to cure diabetes are being explored. Stem cells are being investigated as an alternative therapy for treatment of various diseases including diabetes. Few preclinical studies have also been conducted using undifferentiated MSCs as well as in vitro MSCs differentiated into b islet cells. RESULTS: These stem cell transplant studies have highlighted the benefits of MSCs, which have shown promising results. Few human trials using stem cells have also affirmed the potential of these cells in alleviating the symptoms. CONCLUSION: Stem cell transplantation may prove to be a safe and effective treatment for patients with Type 1 diabetes mellitus.

참고문헌 (94)

참고문헌 신청

Zang L / 2017 / Mesenchymal stem cell therapy in type 2 diabetes mellitus / Diabetol Metab Syndr 9:36

IDF / Diabetes Atlas

Atkinson MA / 2001 / Type I diabetes: new perspectives on disease pathogenesis and treatment / Lancet 358:221~229

DeFronzo RA / 1997 / Pathogenesis of type 2 diabetes : metabolic and molecular implications for identifying diabetes genes / Diabetes Rev 5:177~266

You WP / 2016 / Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth / BMJ Open Diabetes Res Care 4:e000161

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