지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 763 - 774 (12page)
이용수
초록· 키워드
오류제보하기
Autologous bone transplantation is the current gold standard for reconstruction of jawbone defects. Bone regeneration usingmesenchymal stem cells (MSC) is an interesting alternative to improve the current techniques,which necessitate a second site of surgery resulting in donor site morbidity. In this study,we compared the osteogenic ability of jawboneMSC(JB-MSC) withMSC from tissues with neural crest origin, namely, the dental pulp, apical papilla and periodontal ligament. All four types ofMSC were isolated from the same patient (n = 3 donors) to exclude inter-individual variations.TheMSCgrowth and differentiation properties were characterized. The osteogenic differentiation potential in each group of cells was assessed quantitatively to determine if there were any differences between the cell types. All cells expressed the MSC-associated surface markers CD73, CD90, CD105, and CD146 and were negative for CD11b, CD19, CD34, CD45 and HLA-DR. All cell types proliferated at similar rates, exhibited similar clonogenic activity and could differentiate into adipocytes and osteoblasts. An alkaline phosphatase assay, OsteoImageTM assay for mineralization and qRT-PCR measuring the genes runx2, ALP and OCN, indicated that there were no significant differences in the osteogenic differentiation ability between the variousMSCs. In conclusion,we show that from a small segment of jawbone it is possible to isolate sufficient quantities of MSC and that these cells can easily be expanded and differentiated into osteoblasts. JB-MSC appear to be good candidates for future bone regeneration applications in the craniofacial region.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
전기 자극을 이용한 CD271 양성 중간엽줄기세포의 연골세포 분화능
KSBB Journal
2021 .03
-
Coculture Effects on the Osteogenic Differentiation of Human Mesenchymal Stromal Cells
조직공학과 재생의학
2016 .01
-
Isolation and Identification of Mesenchymal Stem Cells from Human Mastoid Bone Marrow
조직공학과 재생의학
2015 .01
-
Effect of Low Temperature on Schwann-Like Cell Differentiation of Bone Marrow Mesenchymal Stem Cells
조직공학과 재생의학
2015 .01
-
MMP13-Overexpressing Mesenchymal Stem Cells Enhance Bone Tissue Formation in the Presence of Collagen Hydrogel
조직공학과 재생의학
2023 .06
-
Electrical stimulation enhances osteogenic differentiation in mesenchymal stem cell
한국생물공학회 학술대회
2019 .10
-
Three-Dimensional Culture of Mesenchymal Stem Cells
조직공학과 재생의학
2015 .01
-
Spreading Shape and Area Regulate the Osteogenesis of Mesenchymal Stem Cells
조직공학과 재생의학
2019 .01
-
Amine plasma-polymerized surface enhance osteogenic differentiation of human mesenchymal stem cell
한국생물공학회 학술대회
2019 .04
-
반려견 치료를 위한 지방 조직 유래 중간엽 줄기세포 확립
한국산학기술학회 논문지
2023 .11
-
Derivation and Differentiation of Bone Marrow Mesenchymal Stem Cells from Osteoarthritis Patients
조직공학과 재생의학
2016 .01
-
Osteogenic Differentiation of Human Mesenchymal Stem Cells Using Osteoblast Extracellular Matrix Incorporated into PEG Scaffold
한국생물공학회 학술대회
2018 .04
-
Hybrid PLGA Scaffold with Bioactive PDRN/BMP2 Nanocomplex for Bone Regeneration using Human Fetal MSCs
한국고분자학회 학술대회 연구논문 초록집
2021 .04
-
Transcriptional regulatory network for the establishment of CD8+ T cell exhaustion
Experimental and Molecular Medicine
2021 .02
-
The Osteogenic Role of Biomaterials Combined with Human-Derived Dental Stem Cells in Bone Tissue Regeneration
조직공학과 재생의학
2023 .04
-
Mesenchymal Stem Cell Spheroids: A Promising Tool for Vascularized Tissue Regeneration
조직공학과 재생의학
2024 .07
-
The role of microRNAs in cell fate determination of mesenchymal stem cells : balancing adipogenesis and osteogenesis
BMB Reports
2015 .01
-
Mitochondrial genome mutations in mesenchymal stem cells derived from human dental induced pluripotent stem cells
BMB Reports
2019 .01
-
고효율 CIGS 태양전지를 위한 CdS 박막의 Cd 소스에 따른 효과에 관한 연구
대한전기학회 학술대회 논문집
2015 .11
-
Enhanced Osteogenic Differentiation of Human Mesenchymal Stem Cells by Regulating the Tension between the Cell and Surface Using Magnetic Nanoparticle-incorporated Cells
한국생물공학회 학술대회
2019 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0