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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 149 - 154 (6page)
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초록· 키워드
오류제보하기
Impaired angiogenesis is a common pathological characteristic of chronic wounds. Therefore, the regulation of angiogenesis is important for proper tissue repair. It was reported that substance P (SP) accelerates wound healing in a skin injury model. SP is degraded by neutral endopeptidase (NEP). Our study shows that systemic co-treatment of SP and thiorphan, an inhibitor of NEP synergically increased the number of α-smooth muscle actin positive-blood vessels in skin wounds. However, there was no synergic improvement in wound contraction and extracellular matrix deposition. Therefore, inhibition of endogenous NEP activity by thiorphan treatment might modulate the effects of SP treatment specifically on accelerating angiogenesis during wound healing. However, the molecular mechanism(s) of the synergic increase in angiogenesis by SP and thiorphan treatment is still unknown.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Dubon MJ / 2015 / Substance P enhances the proliferation and migration potential of murine bone marrow-derived mesenchymal stem cell-like cell lines / Exp Ther Med 9:1185~1191
Hong HS / 2009 / A new role of substance P as an injury-inducible messenger for mobilization of CD29(+)stromal-like cells / Nat Med 15:425~435
Yang L / 2014 / Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor / Diabetes 63:4262~4274
Kant V / 2013 / Topically applied substance P enhanced healing of open excision wound in rats / Eur J Pharmacol 715:345~353
Roques BP / 1993 / Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology / Pharmacol Rev 45:87~146
Hong HS / 2009 / A new role of substance P as an injury-inducible messenger for mobilization of CD29(+)stromal-like cells / Nat Med 15:425~435
Yang L / 2014 / Substance P promotes diabetic corneal epithelial wound healing through molecular mechanisms mediated via the neurokinin-1 receptor / Diabetes 63:4262~4274
Kant V / 2013 / Topically applied substance P enhanced healing of open excision wound in rats / Eur J Pharmacol 715:345~353
Roques BP / 1993 / Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology / Pharmacol Rev 45:87~146
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