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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 155 - 161 (7page)
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초록· 키워드
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Dermal fibroblasts play essential roles in wound healing. However, they lose their normal regenerative functions under certain pathologic conditions such as in chronic diabetic wounds. Here, we show that substance P (SP) rescues the malfunctions of dermal fibroblasts in diabetes. SP increased the proliferation of diabetic dermal fibroblasts dose-dependently, although the effect was lower compared to the SP-stimulated proliferation of normal dermal fibroblasts. In contrast to normal dermal fibroblasts, SP increased the expression level of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1) in diabetic dermal fibroblast hence, rescuing their angiogenic potential. The cellular characteristics of diabetic dermal fibroblasts modulated by SP would be able to accelerate the wound healing process through faster wound contraction and improved angiogenesis in diabetic chronic wounds. Moreover, SP pretreatment into dermal fibroblasts isolated from diabetic patients would be a promising strategy to develop autologous cell therapy for treating diabetic chronic wounds.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Eming SA / 2014 / Wound repair and regeneration:mechanisms, signaling, and translation / Sci Transl Med 6:265sr6
Werner S / 2007 / Keratinocyte-fibroblast interactions in wound healing / J Invest Dermatol 127:998~1008
Bainbridge P / 2013 / Wound healing and the role of fibroblasts / J Wound Care 22:407~412
Epstein EH Jr / 1978 / Human skin collagen. Presence of type I and type III at all levels of the dermis / J Biol Chem 253:1336~1337
이증훈 / 2010 / Stimulation of the Extracellular Matrix Production in Dermal Fibroblasts by Velvet Antler Extract / Annals of Dermatology 22(2):173~179
Werner S / 2007 / Keratinocyte-fibroblast interactions in wound healing / J Invest Dermatol 127:998~1008
Bainbridge P / 2013 / Wound healing and the role of fibroblasts / J Wound Care 22:407~412
Epstein EH Jr / 1978 / Human skin collagen. Presence of type I and type III at all levels of the dermis / J Biol Chem 253:1336~1337
이증훈 / 2010 / Stimulation of the Extracellular Matrix Production in Dermal Fibroblasts by Velvet Antler Extract / Annals of Dermatology 22(2):173~179
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