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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 305 - 313 (9page)
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초록· 키워드
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Background/Aims: Several studies have found that the measurement of fecal calprotectin is useful for the early diagnosis ofinflammatory bowel disease (IBD). We compared the effectiveness of three different fecal calprotectin kits for initial diagnosisin patients with suspected IBD. Methods: We enrolled 31 patients with IBD (18 Crohn’s disease [CD], 11 ulcerative colitis [UC],and two intestinal Behçet’s disease), five with irritable bowel syndrome (IBS), and five with other colitis (four infectious colitisand one intestinal tuberculosis). Diagnosis was based on clinical, laboratory, and endoscopic examinations. Fecal sampleswere obtained at the first diagnosis and calprotectin levels were measured using three different kits (Quantum Blue® Calprotectin,EliATM Calprotectin, and RIDASCREEN® Calprotectin). Results: The overall accuracy for differentiating IBD from IBS orother colitis was 94% and 91%, respectively, for Quantum Blue® (cutoff, 50 mg/g); 92% and 89%, respectively, for EliATM (cutoff,50 mg/g); and 82% and 76%, respectively, for RIDASCREEN® (cutoff, 50 mg/g). In patients with CD, the results of Quantum Blue®Calprotectin and EliATM Calprotectin correlated significantly with levels of the Crohn’s disease activity index (Spearman’s rankcorrelation coefficient, r=0.66 and r=0.49, respectively). In patients with UC, the results of EliATM Calprotectin correlated significantlywith the Mayo score (r=0.70). Conclusions: Fecal calprotectin measurement is useful for the identification of IBD. Theoverall accuracies of the three fecal calprotectin kits are comparable.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Hsu K / 2009 / Anti-infective protective properties of S100 calgranulins / Antiinflamm Antiallergy Agents Med Chem 8:290~305
Tibble J / 2000 / A simple method for assessing intestinal inflammation in Crohn’s disease / Gut 47:506~513
Tibble JA / 2002 / Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease / Gastroenterology 123:450~460
von Roon AC / 2007 / Diagnostic precision of fecal calprotectin for inflammatory bowel disease and colorectal malignancy / Am J Gastroenterol 102:803~813
Gisbert JP / 2009 / Questions and answers on the role of faecal calprotectin as a biological marker in inflammatory bowel disease / Dig Liver Dis 41:56~66
Tibble J / 2000 / A simple method for assessing intestinal inflammation in Crohn’s disease / Gut 47:506~513
Tibble JA / 2002 / Use of surrogate markers of inflammation and Rome criteria to distinguish organic from nonorganic intestinal disease / Gastroenterology 123:450~460
von Roon AC / 2007 / Diagnostic precision of fecal calprotectin for inflammatory bowel disease and colorectal malignancy / Am J Gastroenterol 102:803~813
Gisbert JP / 2009 / Questions and answers on the role of faecal calprotectin as a biological marker in inflammatory bowel disease / Dig Liver Dis 41:56~66
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