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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한예방치과학회 International Journal of Clinical Preventive Dentistry International Journal of Clinical Preventive Dentistry Vol.14 No.3
- 발행연도
- 2018.1
- 수록면
- 157 - 161 (5page)
이용수
초록· 키워드
오류제보하기
Objective: Gelidium amansii is one sort of edible red alga distributed along the coast of Northeast Asian countries. G. amansii has been consumed as an important food source as well as a traditional medicine which was known for its regulatory effects against blood pressure and blood glucose. In this study, antioxidative activity of G. amansii ethanol extract (GAEE) was investigated through analysis of reactive oxygen species (ROS) formation and the induction of antioxidative enzymes in human gingival fibroblast-1 (HGF-1) cells. Methods: ROS scavenging assay and cell viability were used to analyze the antioxidative activity of GAEE in HGF-1 cells. In order to estimate the expression of antioxidative enzymes, Western blot analysis was applied. Results: GAEE significantly scavenged lipopolysaccharide isolated from Porphyromonas gingivalis stimulated intracellular ROS production in a dose-dependent manner without any cytotoxicity. To estimate the antioxidative capacity of GAEE as a potent ROS scavenger, tert-butyl hydroperoxide was applied to induce oxidative initiated cell damage in HGF-1 cells and cell viability was also significantly attenuated by GAEE treatment. Therefore, heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1), have known for their potent antioxidative activity, were analyzed whether they were induced by GAEE treatment or not. Both antioxidative enzymes were also significantly induced by GAEE treatment. In addition, GAEE treatment stimulated the activation of the transcription factor for antioxidative enzymes, nuclear factor erythroid 2-related factor 2 (Nrf2). Conclusion: Consequently, GAEE strengthened HO-1 and NQO1 mediated antioxidative potential through the regulation of Nrf2 pathway in HGF-1 cells.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Hopps E / 2010 / A novel component of the metabolic syndrome: the oxidative stress / Nutr Metab Cardiovasc Dis 20:72~77
Crawford A / 2012 / Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease / Gene 501:89~103
Itoh K / 1997 / An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements / Biochem Biophys Res Commun 236:313~322
Nguyen T / 2009 / The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress / J Biol Chem 284:13291~13295
Chen YH / 2004 / Growth-inhibitory effects of the red alga Gelidium amansii on cultured cells / Biol Pharm Bull 27:180~184
Crawford A / 2012 / Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease / Gene 501:89~103
Itoh K / 1997 / An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements / Biochem Biophys Res Commun 236:313~322
Nguyen T / 2009 / The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress / J Biol Chem 284:13291~13295
Chen YH / 2004 / Growth-inhibitory effects of the red alga Gelidium amansii on cultured cells / Biol Pharm Bull 27:180~184
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