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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 25 - 30 (6page)
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초록· 키워드
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Objectives: Many seaweeds are considered important natural resources since their abundant bioactive compounds. The present study tried to analyze the anti-inflammatory activity of several seaweeds in the human gingival fibroblast (HGF)-1 cells. Methods: Lipopolysaccharide from Porphyromonas gingivalis (LPS-PG), one of the main causes in the progression of periodontal inflammation, was applied to induce inflammatory response in HGF-1 cells. Nitric oxide (NO) was used as one of the hallmarks for inflammation, which was analyzed by the Griess reaction. The protein expression level of inducible NO synthase (iNOS) was identified by the Western blot analysis. Results: Inhibitory effect of NO production was investigated in the ethanol extracts of Asparagopsis taxiformis Trevisan de Saint-Léon (ATEE), Distromium decumbens (Okamura) Levring (DDEE), Galaxaura fastigiata (GFEE), Hypnea japonica Tanaka (HJEE), Myelophycus simplex (Harvey) Papenfuss (MSEE), and Scytosiphon canaliculatus (Setchell & N.L. Gardner) Kogame (SCEE) in LPS-PG stimulated HGF-1 cells. As a result, ATEE and HJEE the most potently inhibited while GFEE and SCEE slightly ameliorated NO production without any cytotoxicity. But, DDEE and MSEE did not exhibit the extraordinary NO inhibitory effect in LPS-PG induced HGF-1 cells. Western blot analysis was also conducted to identify the inhibitory effect of both extracts, ATEE and HJEE that sharply attenuated NO production, in LPS-PG induced HGF-1 cells. ATEE and HJEE mitigated iNOS expression in a dose dependent manner, which was in accordance with the result of NO production. Conclusions: ATEE and HJEE in the algal extracts used in this study drastically reduced the LPS-PG-induced inflammatory response in HGF-1 cells. All of this ATEE and HJEE will be used as candidate substances for treatment and prevention of periodontal disease.
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참고문헌 (20)
참고문헌 신청
Vaia Galimanas / 2014 / Bacterial community composition of chronic periodontitis and novel oral sampling sites for detecting disease indicators / Microbiome 2(1):32
Xiao-Pei Chi / 2014 / Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis lipopolysaccharide-induced expression of IL-6 and IL-8 via NF-κB signalling in periodontal fibroblasts / Archives of Oral Biology 59(9):954~961
Nicola U. Zitzmann / 2008 / Definition and prevalence of peri-implant diseases / Journal of Clinical Periodontology 35:286~291
김현주 / 2018 / 임플란트 주위 질환: 원인 요소 및 미생물학적접근 / 대한구강악안면임플란트학회지 22(3):174~182
Chun-Teh Lee / 2017 / Prevalences of peri-implantitis and peri-implant mucositis: systematic review and meta-analysis / Journal of Dentistry 62:1~12
Xiao-Pei Chi / 2014 / Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis lipopolysaccharide-induced expression of IL-6 and IL-8 via NF-κB signalling in periodontal fibroblasts / Archives of Oral Biology 59(9):954~961
Nicola U. Zitzmann / 2008 / Definition and prevalence of peri-implant diseases / Journal of Clinical Periodontology 35:286~291
김현주 / 2018 / 임플란트 주위 질환: 원인 요소 및 미생물학적접근 / 대한구강악안면임플란트학회지 22(3):174~182
Chun-Teh Lee / 2017 / Prevalences of peri-implantitis and peri-implant mucositis: systematic review and meta-analysis / Journal of Dentistry 62:1~12
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