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Objectives: This study was carried out to analyze the cytotoxicity of cadmium sulfate (CdSO 4 ) and the antioxidative effect of Typha orientalis L. (TO) extract on the oxidative stress induced by cytotoxicity of CdSO 4 in the cultured NIH3T3 fibroblasts. Methods: For this study, the cell viability and the antioxidative effects such as the inhibitory activity of lipid peroxidation (LP) and superoxide dismutase (SOD)-like activity and xanthine oxidase (XO)-inhibitory activity were assessed. Results: The cadmium sulfate significantly decreased cell viability in dose-dependently, and XTT 50 value was measured at 47.4 µM of CdSO 4 . The cytotoxicity of CdSO 4 was determined as highly toxic by Borenfreund and Puerner's toxic criteria. The butylated hydroxytoluene (BHT) as antioxidant significantly increased cell viability injured by CdSO 4 -induced cytotoxicity in these cultures. In the protective effect of TO extract on CdSO 4 -induced cytotoxicity, TO extract remarkably increased the inhibitory ability of LP and XO as well as SOD-like ability. Conclusions: From the above results, it is suggested that the oxidative stress is involved in the cytotoxicity of CdSO 4 , and TO extract effectively protected CdSO 4 -induced cytotoxicity by antioxidative effects. The natural component like TO extract may be a putative therapeutic agent for treatment of the toxicity induced by heavy metallic compound like CdSO 4 correlated with the oxidative stress.
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참고문헌 (33)
참고문헌 신청
장설 / 2015 / 국내 유통 한약재의 중금속 함량 모니터링 -서울과 대구지역 한약재 중심으로 - / 한국환경보건학회지 41(1):30~39
김태윤 / 2016 / 독성물질인 염화카드뮴으로 손상된 배양 NIH3T3 섬유모세포에 대한 애기똥풀 추출물의 항산화 효과 / 대한임상검사과학회지 48(1):1~7
정재윤 / 2014 / 환경오염원인 카드뮴으로 손상된 배양 NIH3T3 섬유모세포에 대한 소리쟁이 추출물의 보호 효과 / 인간식물환경학회지 17(1):15~21
Jin T / 1983 / cadmium toxicity in kidney cells. resistance induced by short term pretreatment in vitro and in vivo / Acta Pharmacol et Toxicol 58(3):137~143
손영우 / 2012 / 염모제 성분인 카드뮴의 세포독성에 대한 시엽추출물의 영향 / 대한미용학회지 8(1):9~15
김태윤 / 2016 / 독성물질인 염화카드뮴으로 손상된 배양 NIH3T3 섬유모세포에 대한 애기똥풀 추출물의 항산화 효과 / 대한임상검사과학회지 48(1):1~7
정재윤 / 2014 / 환경오염원인 카드뮴으로 손상된 배양 NIH3T3 섬유모세포에 대한 소리쟁이 추출물의 보호 효과 / 인간식물환경학회지 17(1):15~21
Jin T / 1983 / cadmium toxicity in kidney cells. resistance induced by short term pretreatment in vitro and in vivo / Acta Pharmacol et Toxicol 58(3):137~143
손영우 / 2012 / 염모제 성분인 카드뮴의 세포독성에 대한 시엽추출물의 영향 / 대한미용학회지 8(1):9~15
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