High Intensity Interval Training Increases Natural Killer Cell Number and Function in Obese Breast Cancer-challenged Mice and Obese Women

Nicole G. Barra; Isabella Y. Fan; Jenna B. Gillen; Marianne Chew; Katarina Marcinko; Gregory R. Steinberg; Martin J. Gibala; Ali A. Ashkar

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저자정보: Nicole G. Barra (Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre McMaster Uni) Isabella Y. Fan (Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre McMaster Uni) Jenna B. Gillen (McMaster University) Marianne Chew (Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre McMaster Uni) Katarina Marcinko (McMaster University) Gregory R. Steinberg (McMaster University) Martin J. Gibala (McMaster University) Ali A. Ashkar (Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre McMaster Uni)

저널정보: 대한암예방학회 대한암예방학회지 대한암예방학회지 제22권 제4호

발행연도: 2017.1

수록면: 260 - 266 (7page)

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High intensity interval training (HIIT) boosts natural killer (NK) cell number and activity in normal weight breast cancer patients; however, whether this occurs in obese individuals is not well established. The goal of this study was to determine whether HIIT effectively boosts NK cells as a therapeutic strategy against breast cancer in an obese mouse model and in overweight/obese women. Diet induced female C57Bl/6 obese mice were assigned to undergo HIIT for four weeks or remain sedentary. Female participants were subjected to a six weeks HIIT protocol. HIIT mice acclimatized to treadmill running were subsequently injected with 5 × 105 polyoma middle T (MT) breast cancer cells intravenously. NK cell number and activation were monitored using flow cytometry, and tumor burden or lipid content evaluated from histological lung and liver tissues, respectively. In both mice and humans, circulating NK cell number and activation (CD3‒NK1.1＋CD27＋ and CD3‒CD56＋, respectively) markedly increased immediately after HIIT. HIIT obese mice had reduced lung tumor burden compared to controls following MT challenge, and had diminished hepatic lipid deposition despite minimal body weight loss. Our findings demonstrate that HIIT can benefit obese individuals by enhancing NK cell number and activity, reducing tumor burden, and enhancing metabolic health.

참고문헌 (30)

참고문헌 신청

Allott EH / 2015 / Obesity and cancer: mechanistic insights from transdisciplinary studies / Endocr Relat Cancer 22:R365~R386

Chan DS / 2014 / Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies / Ann Oncol 25:1901~1914

Vivier E / 2008 / Functions of natural killer cells / Nat Immunol 9:503~510

Cheng M / 2013 / NK cell-based immunotherapy for malignant diseases / Cell Mol Immunol 10:230~252

Imai K / 2000 / Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence:an 11-year follow-up study of a general population / Lancet 356:1795~1799

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이 논문의 저자 정보

Nicole G. Barra

소속기관 Department of Pathology and Molecular Medicine and McMaster Immunology Research Centre McMaster Uni