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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Natural killer (NK) cells have cytotoxic effects on tumor cells and viral pathogens. NK cell-derived exosomes (NK-exosomes) also express typical NK cell markers and cytotoxic molecules, therefore, exert anti-tumor and immune homeostatic activities. In this study, canine NK-exosomes separated from cytotoxic NK cell supernatant carried specific markers such as CD81, Alix, and Perforin 1. We examined the anti-tumor effects of NK-exosomes in an experimental murine model using the canine mammary carcinoma cells, REM134. REM134 cells were xenografted of mammary fat pad of mice. CD133, Bmi-1, MMP-3, IL-6, TNF-α, and PCNA are useful as a molecular marker for tumorigenesis and metastasis. The treatment of canine NK-exosomes inhibited tumor growth and significantly (p<0.01) downregulated the expression of Bmi-1, MMP-3, IL-6, TNF-α, and PCNA in REM134-treated mice.
Also, the expression of CD133, potent cancer stem cell marker, was significantly downregulated in the canine NK-exosomes-treated mice compared with that of the tumor group. Collectively, these results suggested that canine NK-exosomes has a potential capacity for regulation of cancer progression and metastasis against canine mammary carcinoma.
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참고문헌 (46)
참고문헌 신청
Ahmadzada T / 2020 / Extracellular vesicles as biomarkers in malignant pleural mesothelioma : A review / Crit Rev Oncol Hematol 150:102949
Aomatsu N / 2012 / CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer / PloS one 7:e45865
Besse B / 2016 / Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC / Oncoimmunology 5:e1071008
Casado JG / 2017 / Mesenchymal stem cell-derived exosomes : immunomodulatory evaluation in an antigeninduced synovitis porcine model / Front Vet Sci 4:39
Cheng Z / 2019 / Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways / Mol Carcinog 58:1389~1399
Aomatsu N / 2012 / CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer / PloS one 7:e45865
Besse B / 2016 / Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC / Oncoimmunology 5:e1071008
Casado JG / 2017 / Mesenchymal stem cell-derived exosomes : immunomodulatory evaluation in an antigeninduced synovitis porcine model / Front Vet Sci 4:39
Cheng Z / 2019 / Exosome-transmitted p120-catenin suppresses hepatocellular carcinoma progression via STAT3 pathways / Mol Carcinog 58:1389~1399
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