Association of XRCC1 Arg399Gln Polymorphism with Colorectal Cancer Risk: A HuGE Meta Analysis of 35 Studies

Forat-Yazdi, Mohammad; Gholi-Nataj, Mohsen; Neamatzadeh, Hossein; Nourbakhsh, Parisa; Shaker-Ardakani, Hossein

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자료유형: 학술저널

저자정보: Forat-Yazdi, Mohammad (Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences and Health Services) Gholi-Nataj, Mohsen (Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences and Health Services) Neamatzadeh, Hossein (Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences and Health Services) Nourbakhsh, Parisa (Department of Medical Immunology, Kermanshah University of Medical Sciences and Health Services) Shaker-Ardakani, Hossein (Shahid Sadoughi Training Hospital, Shahid Sadoughi University of Medical Sciences and Health Services)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제8호

발행연도: 2015.1

수록면: 3,285 - 3,291 (7page)

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Background: Non-synonymous polymorphisms in XRCC1 hase been shown to reduce effectiveness of DNA repair and be associated with risk of certain cancers. In this study we aimed to clarify any association between XRCC1 Arg399Gln and colorectal cancer (CRC) risk by performing a meta-analysis of published case-control studies. Materials and Methods: PubMed and Google Scholar were searched to explore the association between XRCC1 and CRC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias was assessed by Egger's and Begg's tests. Results: Up to January 2015, 35 case control studies involving 9,114 CRC cases and 13,948 controls were included in the present meta-analysis. The results showed that the Arg399Gln polymorphism only under an allele genetic model was associated with CRC risk (A vs. G: OR 0.128, 95% CI 0.119-0.138, p<0.001). Also, this meta-analysis suggested that the XRCC1 Arg399Gln polymorphism might associated with susceptibility to CRC in Asians (A vs G: OR 0.124, 95% CI 0.112-0.138, p<0.001) and Caucasian (A vs G: OR 0.132, 95% CI 0.119-0.146, p<0.001) only under an allele genetic model. Conclusions: This meta-analysis confirms the association between XRCC1 Arg399Gln polymorphism and CRC risk and suggests that the heterogeneity is not strongly modified by ethnicity and deviation from the Hardy-Weinberg equilibrium.

#Colorectal cancer #XRCC1 #Arg399Gln #polymorphism #meta-analysis

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Forat-Yazdi, Mohammad

소속기관 Department of Internal Medicine, Internationl Campus, Shahid Sadoughi University of Medical Sciences