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논문 기본 정보

자료유형
학술저널
저자정보
Shafinah Ahmad Suhaimi (UPM-MAKNA Cancer Research Laboratory Institute of Bioscience Universiti Putra Malaysia Serdang M) Soon Choy Chan (Perdana University School of Foundation Studies MAEPS Building MARDI Complex Serdang Malaysia) Rozita Rosli (UPM-MAKNA Cancer Research Laboratory Institute of Bioscience Universiti Putra Malaysia 43400 Serd)
저널정보
한국유방암학회 Journal of Breast Cancer Journal of Breast Cancer Vol.23 No.1
발행연도
2020.1
수록면
1 - 9 (9page)

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초록· 키워드

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Matrix metallopeptidase 3 or MMP3, is a zinc-dependent proteolytic enzyme that is involved in various physiological processes via modification of the extracellular matrix. In particular, its over-expression has been associated with cancer metastasis and tumor growth in various cancers including breast cancer. MMP3 gene expression is regulated by several factors such as DNA polymorphisms which also serve as risk factors for breast cancer. As such, DNA polymorphisms of MMP3 have the potential to be utilized as genetic biomarkers for prediction and prognosis of metastatic breast cancer. Presently, genome-wide association studies of MMP3 gene polymorphisms which are associated with breast cancer risk and patient survival in a variety of populations are reviewed. In order to understand the potential role of MMP3 polymorphisms as genetic markers for breast cancer metastasis, the domain structure of MMP3, the regulation of its expression and its role in breast cancer metastasis are also briefly discussed in this review. The emergence of MMP3 gene polymorphisms as prognostic biomarker candidates for breast cancer metastasis may contribute towards improving targeted therapies and categorization of breast cancer cases in order to provide a better and more accurate prognosis.

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