P53 Polymorphism at Codon 72 is Associated with Keratocystic Odontogenic Tumors in the Thai Population

Yanatatsaneejit, Pattamawadee; Boonsrang, Ajaree; Mutirangura, Apiwat; Patel, Vyomesh; Kitkumthorn, Nakarin

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저자정보: Yanatatsaneejit, Pattamawadee (Human Genetics Research Group, Department of Botany, Faculty of Science) Boonsrang, Ajaree (Human Genetics Research Group, Department of Botany, Faculty of Science) Mutirangura, Apiwat (Center of Excellence in Molecular Genetics of Cancer and Human Diseases, Department of Anatomy, Faculty of Medicine, Chulalongkorn University) Patel, Vyomesh (Cancer Research Initiatives Foundation [CARIF], 2nd Floor Outpatient Centre, Sime Darby Medical Centre) Kitkumthorn, Nakarin (Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제5호

발행연도: 2015.1

수록면: 1,997 - 2,001 (5page)

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Objective: To clarify the association between the p53 polymorphism at codon 72 and susceptibility to the sporadic keratocystic odontogenic tumor (KCOT). Design: One hundred KCOTs and 160 match-group healthy controls were genotyped to ascertain the frequency of the p53 codon 72 polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), confirmed by direct sequencing. Results: The frequencies of the Pro/Pro, Arg/Pro, and Arg/Arg genotypes were 23.8%, 49.4%, and 26.9%, respectively, in the controls, while the KCOT cohort demonstrated 43.0%, 39.0%, and 18.0%, respectively. Further analysis suggested that p53 Pro could be a KCOT-susceptible allele (OR (95%CI)=1.77 (1.22 to 2.59), p=0.0024), with a sex-adjusted OR (95%CI) of 1.71 (1.17-2.50), p=0.0046. Moreover, the results indicated that p53 codon 72 Pro homozygous was associated with a two-fold risk of developing KCOT (adjusted OR (95%CI) =2.17(1.23-3.84), p=0.0062). Conclusions: The C/C genotype of P53 gene codon 72 increases the risk of developing sporadic KCOT and may be a useful tool for screening and diagnostic purposes.

#Keratocystic odontogenic tumor #P53 #polymorphism #risk

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Yanatatsaneejit, Pattamawadee

소속기관 Human Genetics Research Group, department of Botany, Faculty of Sciences, Chulalongkorn University