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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 175 - 180 (6page)
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BackgroundIt is widely known that the prognosis of acute myeloid leukemia (AML) depends on chro-mosomal abnormalities. The majority of AML patients relapse and experience a dismal disease course despite initial remission.MethodsWe reviewed the medical records and laboratory findings of 55 AML patients who had relapsed between 2004 and 2013 and who had been treated at the Division of Hematology of the Pusan National University Hospital. ResultsThe event-free survival (EFS) was related to prognostic karyotype classification at the time of diagnosis and relapse (unfavorable vs. favorable or intermediate karyotypes at diag-nosis, 8.2 vs. 11.9 mo, P=0.003; unfavorable vs. favorable or intermediate karyotypes at relapse, 8.2 vs. 11.9 mo, P=0.009). The overall survival (OS) was significantly corre-lated with karyotype classification only at diagnosis (unfavorable vs. favorable or inter-mediate vs. karyotypes at diagnosis, 8.5 vs. 21.8 mo, P=0.001; unfavorable vs. favorable or intermediate karyotypes at relapse, 8.5 vs. 21.2 mo, P=0.136). A change in karyotype between diagnosis and relapse, which is regarded as a factor of resistance against treat-ment, was not a significant prognostic factor for OS, EFS, and post-relapse survival (PRS). A Cox proportional hazards model showed that the combined use of fludarabine, cytosine arabinoside, and granulocyte colony-stimulating factor (FLAG) as a salvage regimen, was a significant prognostic factor for OS (hazard ratio=0.399, P=0.010) and the PRS (hazard ratio=0.447, P=0.031).ConclusionThe karyotype classification at diagnosis predicts survival including PRS in relapsed AML patients as well as in treatment-naïve patients. We suggest that presently, administration of salvage FLAG could be a better treatment option.
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참고문헌 (16)
참고문헌 신청
Bishop JF / 1997 / The treatment of adult acute myeloid leukemia / Semin Oncol 24:57~69
Döhner H / 2010 / Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia-Net / Blood 115:453~474
Craddock C / 2005 / Biology and management of relapsed acute myeloid leukaemia / Br J Haematol 129:18~34
Weltermann A / 2004 / Impact of cytogenetics on the prognosis of adults with de novo AML in first relapse / Leukemia 18:293~302
Breems DA / 2005 / Prognostic index for adult patients with acute myeloid leukemia in first relapse / J Clin Oncol 23:1969~1978
Döhner H / 2010 / Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European Leukemia-Net / Blood 115:453~474
Craddock C / 2005 / Biology and management of relapsed acute myeloid leukaemia / Br J Haematol 129:18~34
Weltermann A / 2004 / Impact of cytogenetics on the prognosis of adults with de novo AML in first relapse / Leukemia 18:293~302
Breems DA / 2005 / Prognostic index for adult patients with acute myeloid leukemia in first relapse / J Clin Oncol 23:1969~1978
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