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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 167 - 173 (7page)
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Background: The long-term prognosis of BK virus-associated nephropathy (BKVAN) in kidney transplant recipients (KTRs) is uncertain. We evaluated the long-term prognosis in KTRs with BKVAN and the clinical significance of BKVAN on post-transplant clinical outcome. Methods: We retrospectively analyzed the medical records of 582 patients who underwent kidney transplant (KT) between 2001 and 2014. We divided the patients into a BKVAN group (15 patients) diagnosed by allograft biopsy and a control group (356 patients). Results: The incidence of BKVAN was 4.0%, and the mean follow-up duration was 93.1 ± 52.3 months. Median time from KT to BKVAN diagnosis was 5.9 months (interquartile range [IQR], 4.4-8.7). In the BKVAN group, 9 (60.0%) KTRs with combined acute rejection progressed to graft failure, and the median time from BKVAN diagnosis to graft failure was 36.2 months (IQR, 9.7-65.5). Death-censored graft survival rate and patient survival rate in the BKVAN group were significantly lower than those in the control group. BKVAN and rejection were independent risk factors for graft failure. In the subgroup analysis, death-censored graft survival rate of KTRs with BKVAN with acute rejection was significantly worst in comparison with similar patients without BKVAN regardless of acute rejection (P ＜ 0.001). Conclusion: The long-term prognosis of BKVAN with acute rejection was very poor because of graft failure caused by inadequate treatment for acute rejection considering BKVAN. Therefore, we should carefully monitor the allograft status of KTRs through regular surveillance tests after treatment for BKVAN with acute rejection.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Hirsch HH / 2002 / Polyomavirus BK nephropathy: a (re-)emerging complication in renal transplantation / Am J Transplant 2:25~30
Johnston O / 2010 / Treatment of polyomavirus infection in kidney transplant recipients: a systematic review / Transplantation 89:1057~1070
Hirsch HH / 2005 / Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations / Transplantation 79:1277~1286
Dall A / 2008 / BK virus nephritis after renal transplantation / Clin J Am Soc Nephrol 3(Suppl 2):S68~S75
Costa C / 2012 / Polyomavirus-associated nephropathy / World J Transplant 2:84~94
Johnston O / 2010 / Treatment of polyomavirus infection in kidney transplant recipients: a systematic review / Transplantation 89:1057~1070
Hirsch HH / 2005 / Polyomavirus-associated nephropathy in renal transplantation: interdisciplinary analyses and recommendations / Transplantation 79:1277~1286
Dall A / 2008 / BK virus nephritis after renal transplantation / Clin J Am Soc Nephrol 3(Suppl 2):S68~S75
Costa C / 2012 / Polyomavirus-associated nephropathy / World J Transplant 2:84~94
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