지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 33 - 40 (8page)
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초록· 키워드
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Background: Chronic antibody-mediated rejection (CABMR) is an important cause of late graft loss. De novo donor-specific antibody (dnDSA) is an important prognostic factor for long-term allograft outcomes. However, the prognosis of CABMR based on the presence of dnDSA is uncertain. Methods: We retrospectively analyzed 35 kidney transplant recipients with CABMR between 2010 and 2018. Fourteen recipients had no detectable DSA, and 21 recipients had detectable DSA. We investigated the pathologic findings at diagnosis of CABMR, allograft function 12 months later, related factors for allograft failure, and allograft survival rate based on the presence of dnDSA. Results: The pathologic findings showed that acute and chronic changes were more severe in the dnDSA (+) group than in the dnDSA (–) group. There was no significant difference in the allograft function 12 months after the diagnosis of CABMR and in the amount of proteinuria at diagnosis between the two groups. However, the death-censored graft survival rate was lower in the high-proteinuria group than in the low-proteinuria group in both groups. The treatment rate of recipients was higher in the dnDSA (+) group than in the dnDSA (–) group; however, there was no significant difference in the death-censored graft survival rate between the two groups. Conclusions: Although the effect of dnDSA on the prognosis of CABMR is not clear, it would be important not to neglect treatment for CABMR with risk factors for allograft failure even without dnDSA. Continuous and rigorous surveillance of DSA and allograft function is needed in patients with CABMR.
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참고문헌 (12)
참고문헌 신청
Haas M / 2018 / The Banff 2017 Kidney Meeting Report:revised diagnostic criteria for chronic active T cell-mediated rejection, antibody-mediated rejection, and prospects for integrative endpoints for next-generation clinical trials / Am J Transplant 18:293~307
Singh N / 2009 / Antibody-mediated rejection: treatment alternatives and outcomes / Transplant Rev(Orlando) 23:34~46
Levey AS / 2007 / Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values / Clin Chem 53:766~772
Roufosse C / 2018 / A 2018 reference guide to the Banff classification of renal allograft pathology / Transplantation 102:1795~1814
Solar-Cafaggi D / 2018 / Antibody-mediated rejection in the Banff classifications of 2007 and 2017 : a comparison of renal graft loss prediction capability / Transpl Immunol 51:40~44
Singh N / 2009 / Antibody-mediated rejection: treatment alternatives and outcomes / Transplant Rev(Orlando) 23:34~46
Levey AS / 2007 / Expressing the Modification of Diet in Renal Disease Study equation for estimating glomerular filtration rate with standardized serum creatinine values / Clin Chem 53:766~772
Roufosse C / 2018 / A 2018 reference guide to the Banff classification of renal allograft pathology / Transplantation 102:1795~1814
Solar-Cafaggi D / 2018 / Antibody-mediated rejection in the Banff classifications of 2007 and 2017 : a comparison of renal graft loss prediction capability / Transpl Immunol 51:40~44
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