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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 155 - 164 (10page)
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Hepatitis C virus (HCV)-related liver disease is the most common indication for liver transplantation (LT) in Western countries, whereas HCV LT is rare in Korea. We conducted a survey of HCV RNA-positive patients who underwent LT and investigated the prognostic factors for patient survival and the effects of immunosuppression. To accomplish this, we retrospectively reviewed the multicenter records of 192 HCV RNA-positive patients who underwent LT. The 1-, 3-, and 5-year overall survival rates were 78.8%, 75.3%, and 73.1%, respectively. Excluding cases of hospital mortality (n=23), 169 patients were evaluated. Most patients were genotype 1 (n=111, 65.7%) or genotype 2 (n=42, 24.9%). The proportion of living donors for LT (n=135, 79.9%) was higher than that of deceased donors (DDLT; n=34, 20.1%). The median donor and recipient ages were 32 and 56 years, respectively. Twenty-eight patients (16.6%) died during the observation period, while 75 underwent universal prophylaxis and 15 received preemptive therapy. HCV recurrence was detected in 97 patients. Recipients who were older than 60, received DDLT, used cyclosporine, or suffered acute rejection had lower rates of survival. Acute rejection was closely associated with a lack of induction therapy, cyclosporine use, and universal prophylaxis after transplantation. The careful avoidance of acute rejection in the post-transplant period through adequate use of tacrolimus is a preferable strategy that increases patient survival following liver transplantation.
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참고문헌 (32)
참고문헌 신청
Mohd Hanafiah K / 2013 / Global epidemiology of hepatitis C virus infection: new estimates of age-specific antibody to HCV seroprevalence / Hepatology 57:1333~1342
European Association for the Study of the Liver / 2011 / EASL Clinical Practice Guidelines: management of hepatitis C virus infection / J Hepatol 55:245~264
Hai-Rim Shin / 2005 / The Prevalence of Hepatitis C Virus Infection in Korea: Pooled Analysis / Journal of Korean Medical Science 20(6):985~988
Kim SJ / 2012 / Viral hepatitis surveillance system and statue of C hepatitis sentinel surveillance in Korea. Public Health Weekly Report :214~219
Lee HW / 2012 / Liver transplantation for hepatitis C virus-related liver disease in Korea / J Korean Soc Transplant 26:269~276
European Association for the Study of the Liver / 2011 / EASL Clinical Practice Guidelines: management of hepatitis C virus infection / J Hepatol 55:245~264
Hai-Rim Shin / 2005 / The Prevalence of Hepatitis C Virus Infection in Korea: Pooled Analysis / Journal of Korean Medical Science 20(6):985~988
Kim SJ / 2012 / Viral hepatitis surveillance system and statue of C hepatitis sentinel surveillance in Korea. Public Health Weekly Report :214~219
Lee HW / 2012 / Liver transplantation for hepatitis C virus-related liver disease in Korea / J Korean Soc Transplant 26:269~276
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