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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 176 - 181 (6page)
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초록· 키워드
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Background: Although early monitoring of BK virus infection in renal transplant patients has led to improved outcomes over the past decade, it remains unclear whether monitoring for viremia is the best screening tool for BK virus nephropathy (BKVN). Methods: We conducted a retrospective review of the medical records of 368 renal transplant recipients who had a minimum of 18 months of posttransplantation follow-up. The relationship between the presence of BK viruria and a composite end point of BK viremia/BKVN was established, and the predictive value of high-grade BK viruria for development of viremia/BKVN was determined. Results: High grade of BK viruria was present in 110 (30.1%) of the renal transplant recipients. BK viremia/BKVN was present in 64 (17.4%) patients and was 50 times more likely to be present in patients with high-grade BK viruria. The risk of developing BK viremia/BKVN was 3 times higher in high-grade viruria patients, and viruria preceded viremia by nearly 7 weeks. Conclusion: The presence of high-grade viruria is an early marker for developing BK viremia/BKVN. Detection of high-grade viruria should prompt early allograft biopsy and/or preemptive reduction in immunosuppression.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Gardner SD / 1971 / New human papo-vavirus (B.K.) isolated from urine after renal transplantation / Lancet 19:1253~1257
Egli A / 2009 / Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors / J Infect Dis 199:837~846
Knowles WA / 2003 / Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40 / J Med Virol 71:115~123
Polo C / 2004 / Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children / Clin Microbiol Infect 10:640~644
Zhong S / 2007 / Age-related urinary excretion of BK polyomavirus by nonimmunocompromised individuals / J Clin Microbiol 45:193~198
Egli A / 2009 / Prevalence of polyomavirus BK and JC infection and replication in 400 healthy blood donors / J Infect Dis 199:837~846
Knowles WA / 2003 / Population-based study of antibody to the human polyomaviruses BKV and JCV and the simian polyomavirus SV40 / J Med Virol 71:115~123
Polo C / 2004 / Prevalence and patterns of polyomavirus urinary excretion in immunocompetent adults and children / Clin Microbiol Infect 10:640~644
Zhong S / 2007 / Age-related urinary excretion of BK polyomavirus by nonimmunocompromised individuals / J Clin Microbiol 45:193~198
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