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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 450 - 457 (8page)
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초록· 키워드
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Background: Evidence of antibody-mediated injury in the absence of donor-specific HLA antibodies (HLA-DSA) has recently emerged, suggesting a role of antibodies in targeting non-HLA antigens expressed on renal allograft tissue. However, the clinical significance of pre-transplant non-HLA antibodies remains unclear. We compared the histological and clinical impact of pre-transplant HLA-DSA and non-HLA antibodies, especially angiotensin II type I receptor (anti-AT1R) and MHC class I-related chain A (anti-MICA), in kidney transplant patients. Methods: Pre-transplant HLA-DSA, anti-AT1R, and anti-MICA were retrospectively examined in 359 kidney transplant patients to determine the effect of each antibody on allograft survival and clinical characteristics. Results: Pre-transplant HLA-DSA, anti-AT1R, and anti-MICA were detected in 37 (10.3%), 174 (48.5%), and 50 patients (13.9%), respectively. Post-transplant antibody-mediated rejection was associated with a pre-transplant HLA-DSA (+) status only. The development of microvascular inflammation (MVI) was associated with pre-transplant HLA-DSA (P=0.001) and anti-AT1R (P=0.036). Anti-AT1R (+) patients had significantly lower allograft survival compared with anti-AT1R (−) patients (P=0.042). Only pre-transplant anti-AT1R positivity was an independent risk factor for allograft failure (hazard ratio 4.824, confidence interval 1.017–24.888; P=0.038). MVI was the most common histological feature of allograft failure in patients with pre-transplant anti-AT1R. Conclusions: Pre-transplant anti-AT1R is an important risk factor for allograft failure, which may be mediated by MVI induction in the allograft tissue.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Terasaki PI / 2004 / Predicting kidney graft failure by HLA antibodies: a prospective trial / Am J Transplant 4:438~443
Loupy A / 2013 / Complement-binding anti-HLA antibodies and kidney-allograft survival / N Engl J Med 369:1215~1226
Wiebe C / 2012 / Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant / Am J Transplant 12:1157~1167
Opelz G / 2005 / Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies / Lancet 365:1570~1576
Tait BD / 2013 / Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation / Transplantation 95:19~47
Loupy A / 2013 / Complement-binding anti-HLA antibodies and kidney-allograft survival / N Engl J Med 369:1215~1226
Wiebe C / 2012 / Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant / Am J Transplant 12:1157~1167
Opelz G / 2005 / Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies / Lancet 365:1570~1576
Tait BD / 2013 / Consensus guidelines on the testing and clinical management issues associated with HLA and non-HLA antibodies in transplantation / Transplantation 95:19~47
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