지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.5
- 수록면
- 384 - 392 (9page)
이용수
초록· 키워드
오류제보하기
Molecular characterization of swine leukocyte antigen (SLA) genes is important for elucidating the immune responses between swine-donor and human-recipient in xenotransplantation. Examination of associations between alleles of SLA class I genes, type of pig genetic modification, porcine endogenous retrovirus (PERV) viral titer, and PERV subtypes may shed light on the nature of xenograft acceptance or rejection and the safety of xenotransplantation. No significant difference in PERV gag RNA level between transgenic and non-transgenic pigs was noted; likewise, the type of applied transgene had no impact on PERV viremia. SLA-1 gene profile type may correspond with PERV level in blood and thereby influence infectiveness. Screening of pigs should provide selection of animals with low PERV expression and exclusion of specimens with PERV-C in the genome due to possible recombination between A and C subtypes, which may lead to autoinfection. Presence of PERV-C integrated in the genome was detected in 31.25% of specimens, but statistically significant increased viremia in specimens with PERV-C was not observed. There is a need for multidirectional molecular characterization (SLA typing, viremia estimation, and PERV subtype screening) of animals intended for xenotransplantation research in the interest of xeno-recipient safety.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulation of porcine endogenous retrovirus by dual LTR1+2 (Long Terminal Region) miRNA in primary porcine kidney cells
Journal of Veterinary Science
2019 .09
-
Considering the use of Xenotransplantation Products in pig
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Swine leukocyte antigen and Human leukocyte antigen matched analysis for solid organ xenotransplantation
한국실험동물학회 학술발표대회 논문집
2016 .08
-
The results of xenotransplantation for transgenic type
한국실험동물학회 학술발표대회 논문집
2025 .02
-
How to make transgenic pig for xenotransplantation?
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Transgenic type of miniature pig for xenotransplantation
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Future transgenic type to improve the results of xenotransplantation
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Results of pig to monkey heterotopic cardiac xenotransplantation in Korea
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Current status of xenotransplantation
한국실험동물학회 학술발표대회 논문집
2022 .01
-
Transgenic pigs: methods of production and its applications
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Low-level viremia in patients undergoing antiviral therapy: Does it indicate time for a change?
Clinical and Molecular Hepatology
2020 .01
-
Production of multiple transgenic pig for xenotransplantation of non-human primate
한국실험동물학회 학술발표대회 논문집
2019 .01
-
How does low-level viremia affect the prognosis of patients with chronic hepatitis B?
Clinical and Molecular Hepatology
2020 .01
-
Optimal development method for transgenic pigs using endogenous promoter-mediated expression via knock-in for xenotransplantation
한국실험동물학회 학술발표대회 논문집
2025 .02
-
Production of Minimized Transgenic Pig for Biomedical Research
한국실험동물학회 학술발표대회 논문집
2020 .02
-
Recent progress in pig to non-human primate(NHP) solid organ xenotransplantation in Korea
한국실험동물학회 학술발표대회 논문집
2018 .07
-
Historical Review and Future of Cardiac Xenotransplantation
Korean Circulation Journal
2023 .06
-
이종장기이식의 최신지견
Clinical Transplantation and Research
2016 .01
-
Immunotherapy strategies for clinical approval in solid organ xenotransplantation
한국실험동물학회 학술발표대회 논문집
2025 .02
-
History of xeno-islets and recent new researches from transgenic pigs’ islets
한국실험동물학회 학술발표대회 논문집
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-528-001366822