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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 366 - 369 (4page)
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초록· 키워드
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The purpose of the current study was to compare prognostic outcomes between patients with high-grade ovarian Sertoli-Leydigcell tumors (SLCTs) and those with other low-grade SLCTs. We retrospectively reviewed medical records for 24 patients pathologicallydiagnosed with SLCTs between 2006 to 2019 at two institutions. The patients were grouped according to pathological grade:SLCT was classified as grade 1, well differentiated; grade 2, intermediated differentiated; or grade 3, poorly differentiated (Meyer’sclassification). Statistical analysis was performed to compare survival outcomes according to pathological grade. The median patientage was 42.5 years (range 16?75). Eighteen patients (75%) were International Federation of Gynecology and Obstetrics stageI, and none were diagnosed in stage IV. Nine patients (37.5%) were grade 3, and 15 patients (63.5%) were grades 1?2. When comparingclinical baseline characteristics of the grade 1?2 group with those of the grade 3 group, only serum CA125 level at diagnosiswas significantly higher in the grade 3 group (38.34 vs. 382.29, p=0.002). Five patients experienced recurrence of grade 3 disease,while no recurrence was reported in grade 1?2 disease. Four of the five recurrent patients died. In result, grade 3 ovarian SLCTshowed significantly poorer prognosis than grade 1?2 disease (overall survival, hazard ratio=14.25, 95% confidence interval=1.881?108.0; log-rank p=0.010). Our findings were consistent with the concept that patients with stage I/grade 1?2 tumors have agood prognosis without adjuvant chemotherapy. Since grade 3 ovarian SLCT appears to be relatively more fatal than grade 1 or 2,patients with grade 3 SLCT might require more aggressive surgical intervention and post-treatment surveillance.
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참고문헌 (11)
참고문헌 신청
Zaloudek C / 1984 / Sertoli-Leydig tumors of the ovary. A clinicopathologic study of 64 intermediate and poorly differentiated neoplasms / Am J Surg Pathol 8:405~418
Sachdeva P / 2008 / Sertoli-Leydig cell tumor : a rare ovarian neoplasm. Case report and review of literature / Gynecol Endocrinol 24:230~234
Bhat RA / 2013 / Sertoli-Leydig cell tumor of the ovary : analysis of a single institution database / J Obstet Gynaecol Res 39:305~310
Gee DC / 1981 / The pathological assessment of ovarian neoplasms. IV : The sex cord-stromal tumours / Pathology 13:235~255
Roth LM / 1981 / Sertoli-Leydig cell tumors : a clinicopathologic study of 34 cases / Cancer 48:187~197
Sachdeva P / 2008 / Sertoli-Leydig cell tumor : a rare ovarian neoplasm. Case report and review of literature / Gynecol Endocrinol 24:230~234
Bhat RA / 2013 / Sertoli-Leydig cell tumor of the ovary : analysis of a single institution database / J Obstet Gynaecol Res 39:305~310
Gee DC / 1981 / The pathological assessment of ovarian neoplasms. IV : The sex cord-stromal tumours / Pathology 13:235~255
Roth LM / 1981 / Sertoli-Leydig cell tumors : a clinicopathologic study of 34 cases / Cancer 48:187~197
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