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The Study on Possibility of Use of Lead in Plasma as a Chronic Toxicity Biomarker
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혈장 중 납의 만성독성 지표로의 활용에 관한 연구

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Type
Academic journal
Author
Lee, Sung-Bae (산업안전보건연구원 산업화학연구실) Lim, Cheol-Hong (산업안전보건연구원 산업화학연구실) Kim, Nam Soo (순천향대학교 환경산업의학연구소)
Journal
Korean Industrial Hygiene Association 한국산업보건학회지 한국산업보건학회지 제29권 제2호 KCI Accredited Journals
Published
2019.1
Pages
195 - 207 (13page)

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The Study on Possibility of Use of Lead in Plasma as a Chronic Toxicity Biomarker
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Research history (2)

2019

The Study on Possibility of Use of Lead in Plasma as a Chronic Toxicity Biomarker
Lee ,  Sung-Bae ,  Lim 한국산업보건학회지 2019.01 Academic journal

2014

(The) study on utility of plasma lead level as lead toxicity biomarker
이성배 환경과학과 2014.01 Thesis
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Abstract· Keywords

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Objectives: This study was performed to confirm whether plasma lead can be used as a chronic biomarker for the biological monitoring of exposure to lead. Methods: Lead concentrations in 66 plasma samples from retired lead workers (G.M. 60.25 years, Median 61.00 years) and 42 plasma samples from the general population (G.M. 53.76 years, Median 56.50 years) were measured using ICP/Mass. Tibia, whole blood, hemoglobin, hematocrit, and blood zinc protophorphyrin (ZPP) concentrations and urinary ${\delta}$-aminolevulinic acid (${\delta}-ALA$) were measured for correlation analysis with plasma lead. Results: The geometric mean concentration of lead in plasma was $0.23{\mu}g/L$ for the retired lead workers and $0.10{\mu}g/L$ for the general population sample. A simple correlation analysis of biomarkers showed that plasma lead concentration among the retired lead workers was highly correlated with lead concentration in the tibia and with blood lead concentration, and the plasma lead concentration among the general population correlated with ZPP concentration in the blood. The lead concentration in the tibia and the lead concentration in the whole blood increased with length of working period. As the period in the lead workplace increased, the ratio of lead in plasma to lead concentration in whole blood decreased. Conclusion: This study confirmed the possibility of a chronic biomarker of lead concentration in blood plasma as a biomarker. In the future, comparative studies with specific indicators will lead to more fruitful results.
#General population #ICP/Mass #lead #plasma #retired lead worker

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References (31)

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American Conference of Governmental Industrial Hygienists / 2001 / Lead, elemental and inorganic / ACGIH lead BEI1-15 google schola Fernando Barbosa / 2005 / A Critical Review of Biomarkers Used for Monitoring Human Exposure to Lead: Advantages, Limitations, and Future Needs / Environmental Health Perspectives 113(12):1669~1674 Crossref Behinaein S / 2017 / Age and sex influence on bone and blood lead concentrations in a cohort of the general population living in Toronto / Physiol Meas 38(3):431~451 Crossref Ingvar A. Bergdahl / 1999 / Lead in Plasma and Whole Blood from Lead-Exposed Children / Environ research section A 80(1):25~33 Crossref Ingvar A. Bergdahl / 2008 / Biomonitoring of Lead Exposure—Alternatives to Blood / Journal of Toxicology and Environmental Health, Part A 71(18):1235~1243 Crossref

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