De novo transcriptome sequencing of marine-derived Aspergillus glaucus and comparative analysis of metabolic and developmental variations in response to salt stress

Shaomei Liu; Jiaxin Li; Yuan Wu; Yanna Ren; Qi Liu; Qiyao Wang; Xiangshan Zhou; Menghao Cai; Yuanxing Zhang

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자료유형: 학술저널

저자정보: Shaomei Liu (East China University of Science and Technology) Jiaxin Li (East China University of Science and Technology) Yuan Wu (East China University of Science and Technology) Yanna Ren (East China University of Science and Technology) Qi Liu (East China University of Science and Technology) Qiyao Wang (East China University of Science and Technology) Xiangshan Zhou (East China University of Science and Technology) Menghao Cai (East China University of Science and Technology) Yuanxing Zhang (Shanghai Collaborative Innovation Center for Biomanufacturing)

저널정보: 한국유전학회 Genes & Genomics Genes & Genomics Vol.39 No.3

발행연도: 2017.1

수록면: 317 - 329 (13page)

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Aspergillus glaucus HB1-19 is a typical marinederived fungus preferring the dependence on sea water for its growth, asexual development and polyketides biosynthesis. Therein, salt stress greatly functions even in superior to light illumination, which is also a critical regulation signal for fungi. Here, comparative RNA-seq analysis of this strain was performed under conditions of saltstress ? dark (group A), non salt-stress ? dark (group B), salt-stress ? light (group C). The RNA-seq generated a total of 19,024 unigenes with an average length of 1415 bp. Differentially expressed genes were very similar between group A and group C but greatly differed between group A and group B, proving that salt stress functioned superior to light illumination globally. Salt stress highly enhanced primary metabolism and activated Ras and MAPK signaling pathways. There seems no direct interaction between asexual development and polyketides biosynthesis. Salt stress inhibited terpenoids biosynthesis but showed little influences on polyketide pathway as well as other secondary metabolism pathways. These findings provide a better understanding of marine fungi adapting to marine environment. Also, it indicates that the so-called ‘salt stress-induced’ may truly be a ‘metal ions-induced’ for biosynthesis of secondary metabolites in marine fungi.

참고문헌 (46)

참고문헌 신청

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