지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,085 - 1,094 (10page)
이용수
초록· 키워드
오류제보하기
Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Bruin SC / 2010 / Specific genomic aberrations in primary colorectal cancer are associated with liver metastases / BMC Cancer 10:662
Bruin SC / 2013 / Selection of Patients for Hepatic Surgery of Colorectal Cancer Liver Metastasis Based on Genomic Aberrations / Ann Surg Oncol Suppl 3:S560~S569
Carvalho B / 2009 / Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression / Gut 58:79~89
Chen HW / 2008 / Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1 / Cancer Res 68:7428~7438
DeRycke MS / 2009 / S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival / Am J Clin Pathol 132:846~856
Bruin SC / 2013 / Selection of Patients for Hepatic Surgery of Colorectal Cancer Liver Metastasis Based on Genomic Aberrations / Ann Surg Oncol Suppl 3:S560~S569
Carvalho B / 2009 / Multiple putative oncogenes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression / Gut 58:79~89
Chen HW / 2008 / Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1 / Cancer Res 68:7428~7438
DeRycke MS / 2009 / S100A1 expression in ovarian and endometrial endometrioid carcinomas is a prognostic indicator of relapse-free survival / Am J Clin Pathol 132:846~856
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Analysis of Intestinal Mucosal Microbiome Changes before and after Chemoradiation in Locally Advanced Rectal Cancer Patients
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2019 .12
-
Treatment Planning Volume According to Change in Bladder Volume in Therapy of Proton Beam in Magnetic Field
Journal of Magnetics
2017 .12
-
Genetic Change from Colorectal Carcinoma Patients Using Comparative Genomic Hybridization
대한임상검사과학회지
2015 .01
-
LC-MS/MS-based Proteomic Analysis of Locally Advanced Rectal Tumors to Identify Biomarkers for Predicting Tumor Response to Neoadjuvant Chemoradiotherapy
Mass Spectrometry Letters
2022 .09
-
Rare minisatellite alleles of MUC2-MS8 influence susceptibility to rectal carcinoma
Genes & Genomics
2021 .12
-
Emerging role for R-loop formation in hepatocellular carcinoma
Genes & Genomics
2023 .05
-
Genomic and Metabolic Features of Enterococcus faecium Revealed by Pan-genomic and Metatranscriptomic Analysis
한국미생물학회 학술대회논문집
2020 .10
-
Molecular fossils “pseudogenes” as functional signature in biological system
Genes & Genomics
2020 .01
-
HPLC와 중수소 충돌기체 ICP/MS를 이용하여 분석한 셀레노단백질과 한국인 직장암과의 상관관계 연구
대한화학회지
2019 .12
-
Genomic Information of Kimchi-associated Microbes for Developing Useful New Materials (Big Issue Group Project)
한국미생물학회 학술대회논문집
2018 .04
-
Relationship between spatial organization and biological function, analyzed using gene ontology and chromosome conformation capture of human and fission yeast genomes
Genes & Genomics
2016 .01
-
An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts
Molecules and Cells
2016 .02
-
A study to find a new specific target that induces brain metastasis in triple-negative breast cancer
한국분석과학회 학술대회
2022 .05
-
Isolation and Genomic Study of Marine SAR202 Bacteria
한국미생물학회 학술대회논문집
2021 .08
-
Identifying Vulnerabilities in Fungal Pathogens through Functional and Chemical Genomic Analyses
한국미생물학회 학술대회논문집
2021 .08
-
Genomic Analysis of Microorganisms Isolated from Kimchi and Human
한국미생물학회 학술대회논문집
2019 .04
-
Fungal Genomics in Dermatology
대한의진균학회지
2019 .01
-
A Database of Gene Expression Profiles of Korean Cancer Genome
Genomics & informatics
2015 .01
-
Genomics, Metagenomics, and Systems Understanding of Microbial Life
한국미생물학회 학술대회논문집
2019 .04
-
High Speed and Sensitive X-ray Analysis System with Automated Aberration Correction Scanning Transmission Electron Microscope
한국현미경학회지
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0