지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.4
- 수록면
- 173 - 186 (14page)
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초록· 키워드
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BACKGROUD/OBJECTIVES: Alzheimer"s disease (AD) is the most common cause of dementia in the elderly. Due to the increased incidence of dementia, there is a corresponding increase concerning the importance of AD. In this study, we investigated the protective effects conferred by Zizyphus jujuba (Zj) and Zizyphus jujuba fermented by yeast (Zj-Y), on cognitive impairment in an AD mouse model.
MATERIALS/METHODS: AD was induced by injecting amyloid beta<SUB>25-35</SUB> (Aβ<SUB>25-35</SUB>) in ICR mice, and subsequently 200 mg/kg Zj or Zj-Y was administered daily for 14 days. The cognitive ability of AD mice was observed through behavioral experiments in T-maze, novel object recognition, and Morris water maze tests. We subsequently measured the levels of malondialdehyde (MDA), nitric oxide (NO), aspartate aminotransferase, and alanine aminotransferase in either tissues or serum.
RESULTS: In behavioral tests, deterioration was revealed in the short- and long-term learning and memory functions in the Aβ<SUB>25-35</SUB>-injected control group compared to the normal group, indicating that Aβ<SUB>25-35</SUB> injection impairs cognitive functions. However, administration of Zj and Zj-Y improved cognitive function in mice, as compared to the Aβ<SUB>25-35</SUB>-injected control mice. In addition, the Aβ<SUB>25-35</SUB> induced elevations of MDA and NO in the brain, kidney, and liver were suppressed after exposure to Zj and Zj-Y. Especially, Zj-Y showed stronger scavenging effect against MDA and NO, as compared to Zj.
CONCLUSIONS: Results of the present study indicate that Zj-Y exerts a protective effect on cognitive impairment and memory dysfunction, which is exerted by attenuating the oxidative stress induced by Aβ<SUB>25-35</SUB>.
MATERIALS/METHODS: AD was induced by injecting amyloid beta<SUB>25-35</SUB> (Aβ<SUB>25-35</SUB>) in ICR mice, and subsequently 200 mg/kg Zj or Zj-Y was administered daily for 14 days. The cognitive ability of AD mice was observed through behavioral experiments in T-maze, novel object recognition, and Morris water maze tests. We subsequently measured the levels of malondialdehyde (MDA), nitric oxide (NO), aspartate aminotransferase, and alanine aminotransferase in either tissues or serum.
RESULTS: In behavioral tests, deterioration was revealed in the short- and long-term learning and memory functions in the Aβ<SUB>25-35</SUB>-injected control group compared to the normal group, indicating that Aβ<SUB>25-35</SUB> injection impairs cognitive functions. However, administration of Zj and Zj-Y improved cognitive function in mice, as compared to the Aβ<SUB>25-35</SUB>-injected control mice. In addition, the Aβ<SUB>25-35</SUB> induced elevations of MDA and NO in the brain, kidney, and liver were suppressed after exposure to Zj and Zj-Y. Especially, Zj-Y showed stronger scavenging effect against MDA and NO, as compared to Zj.
CONCLUSIONS: Results of the present study indicate that Zj-Y exerts a protective effect on cognitive impairment and memory dysfunction, which is exerted by attenuating the oxidative stress induced by Aβ<SUB>25-35</SUB>.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2021-594-001557656