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논문 기본 정보

자료유형
학술저널
저자정보
신말순 (고려대학교) 김태운 (경희대학교) 이재민 (경희대학교) 지은상 (경희대학교) 임백빈 (동서대학교)
저널정보
한국운동재활학회 Journal of exercise rehabilitation Journal of exercise rehabilitation Vol.13 No.1
발행연도
2017.1
수록면
30 - 35 (6page)

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Parkinson disease is one of the common brain diseases caused by do-paminergic neuronal loss in the substantia nigra and dopaminergic fiber loss in the striatum. In the present study, the effects of treadmill exer-cise on motor performance, dopaminergic loss of neurons and fibers, and α-synuclein expression in the nigrostriatum were evaluated using rotenone-induced Parkinson rats. For the induction of Parkinson rats, 3-mg/kg rotenone was injected, once a day for 14 consecutive days. Treadmill running was conducted for 30 min once a day during 14 con-secutive days. Rota-rod test for motor balance and coordination and immunohistochemistry for tyrosine hydroxylase and α-synuclein in the nigrostriatum were performed. In the present study, motor balance and coordination was disturbed by induction of rotenone-induced Parkin-son disease, in contrast, treadmill exercise alleviated motor dysfunction in the rotenone-induced Parkinson rats. Nigrostriatal dopaminergic loss of neurons and fibers was occurred by induction of rotenone-induced Parkinson disease, in contrast, treadmill exercise alleviated nigrostriatal dopaminergic loss of neurons and fibers in the rotenone-induced Par-kinson rats. α-Synuclein expression in the nigrostriatum was enhanced by induction of rotenone-induced Parkinson disease, in contrast, tread-mill exercise suppressed α-synuclein expression in the rotenone-in-duced Parkinson rats. Treadmill exercise improved motor function through preservation of nigrostriatal dopaminergic neurons and fibers and suppression of nigrostriatal formation of Lewy bodies in rote-none-induced Parkinson rats.

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