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논문 기본 정보

자료유형
학술저널
저자정보
지은상 (경희대학교) 이재민 (경희대학교) 김태운 (상명대학교 운동재활연구소) 김유미 (한국체육대학교) 김연수 (서남대학교) 김기정 (울산대학교)
저널정보
한국운동재활학회 Journal of exercise rehabilitation Journal of exercise rehabilitation Vol.13 No.2
발행연도
2017.1
수록면
130 - 136 (7page)

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Postpartum depression (PPD) is defined as the depressive symptoms that occur from the moment of delivery until 12 months after delivery. PPD symptoms are closely associated with reduced activity of the se-rotonergic system. Serotonin (5-hydroxytryptamine, 5-HT) plays an im-portant role in the pathogenesis of depression. Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of 5-HT biosynthesis in the seroto-nergic neurons. Exercise exerts anti-depressive effect on depression patients as well as on animal models of depression. In the present study, the effect of treadmill exercise on PPD was investigated using rats. For this study, open field test for activity and forced swimming test for depressive symptoms, and immunohistochemistry for 5-HT and TPH were conducted. The rats in the exercise groups were forced to run on a motorized treadmill for 30 min once a day for 2 weeks. Activity in the open field test was decreased in the postpartum rats, however, per-forming treadmill running increased activity in the postpartum rats. The climbing time was decreased and the immobility time was increased in the postpartum rats. Treadmill exercise increased climbing time and suppressed immobility time in the postpartum rats. 5-HT and TPH ex-pressions in the dorsal raphe were suppressed in the postpartum rats, and treadmill exercise enhanced 5-HT and TPH expressions in the postpartum rats. Treadmill exercise ameliorated the PPD very effective-ly by enhancing serotonin level.

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