지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 392 - 397 (6page)
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초록· 키워드
오류제보하기
Maternal obesity is known to increase the likelihood of offspring becoming obese, high blood pressure, and other metabolic disorders. After inducing obesity, the effect of treadmill exercise in maternal rats during pregnancy on short-term memory was investigated in relation to neurogenesis in rat pups. Short-term memory was declined in rat pups born to obese maternal rats, and treadmill running during pregnancy alleviated short-term memory impairment in rat pups born to obese maternal rats. The number of doublecortin (DCX)-positive and 5-bromo-2′-deoxyuridine (BrdU)-positive cells in the hippocampal dentate gyrus was decreased in rat pups born to obese maternal rats. Treadmill running during pregnancy increased the number of DCX-positive and BrdU-positive cells in rat pups born to obese maternal rats. Expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) in the hippocampus was decreased in the rat pups born to obese maternal rats. Treadmill running during pregnancy increased the expressions of BDNF and TrkB in rat pups born to obese maternal rats. Enhancing effect of short-term memory by treadmill exercise may be due to increased neurogenesis through activation of the BDNF-TrkB signaling pathway by treadmill exercise.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Akhavan MM / 2008 / Serotonergic and noradrenergic lesions suppress the enhancing effect of maternal exercise during pregnancy on learning and memory in rat pups / Neuroscience 15:1173~1183
Bilbo SD / 2010 / Enduring consequences of maternal obesity for brain inflammation and behavior of offspring / FASEB J 24:2104~2115
Bramham CR / 2005 / BDNF function in adult synaptic plasticity : the synaptic consolidation hypothesis / Prog Neurobiol 76:99~125
Chang GQ / 2008 / Maternal high-fat diet and fetal programming : increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity / J Neurosci 28:12107~12119
Couillard-Despres S / 2001 / Molecular mechanisms of neuronal migration disorders, quo vadis / Curr Mol Med 1:677~688
Bilbo SD / 2010 / Enduring consequences of maternal obesity for brain inflammation and behavior of offspring / FASEB J 24:2104~2115
Bramham CR / 2005 / BDNF function in adult synaptic plasticity : the synaptic consolidation hypothesis / Prog Neurobiol 76:99~125
Chang GQ / 2008 / Maternal high-fat diet and fetal programming : increased proliferation of hypothalamic peptide-producing neurons that increase risk for overeating and obesity / J Neurosci 28:12107~12119
Couillard-Despres S / 2001 / Molecular mechanisms of neuronal migration disorders, quo vadis / Curr Mol Med 1:677~688
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