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자료유형
학술저널
저자정보
조한샘 (상명대학교) 김태운 (경희대학교) 지은상 (경희대학교) 박혜상 (경희대학교 의과대학 생리학교실) 신말순 (고려대학교) 백성수 (상명대학교)
저널정보
한국운동재활학회 Journal of exercise rehabilitation Journal of exercise rehabilitation Vol.12 No.4
발행연도
2016.1
수록면
293 - 298 (6page)

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Autism is a complex developmental disorder with impairments in social interaction, communication, repetitive behavior and motor skills. Exer-cise enhances cognitive function, ameliorates motor dysfunction, and provides protective profits against neurodegeneration. In the present study, we evaluated the effect of treadmill exercise on the motor coor-dination and Purkinje cell loss in relation with reactive astrocytes and microglial activation in the cerebellum using valproic acid (VPA)-in-duced autism rat model. On the 12th day of pregnancy, the pregnant rats in the VPA-exposed group received intraperitoneal injections of 600-mg/kg VPA. After birth, the rat pups were divided into four groups: the control group, the exercise group, the VPA-treated group, the VPA- treated and exercise group. The rat pups in the exercise groups were forced to run on a treadmill for 30 min once a day, 5 times a week for 4 weeks. In the present results, motor balance and coordination was dis-turbed by induction of autism, in contrast, treadmill exercise alleviated motor dysfunction in the autistic rats. Purkinje cell loss, reactive astro-cytes, and microglial activation were occurred by induction of autism, in contrast, treadmill exercise enhanced survival rate of Purkinje neu-rons through inhibition of reactive astrocytes and microglia in the autis-tic rats. The present study showed that exercise may provide a potential therapeutic strategy for the alleviation of motor dysfunction in autistic patients.

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