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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,937 - 1,942 (6page)
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초록· 키워드
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The worldwide seroprevalence of hepatitis A virus (HAV) and hepatitis B virus (HBV) has changed over the last two decades, indicating a declining incidence of HAV and HBV infections. Therefore, vaccinations against HAV and HBV are recommended for unimmunized people before traveling to an endemic area. Unfortunately, primary antibody deficiency (PAD) patients can only obtain humoral immunity through intravenous immunoglobulin G (IVIG) replacement and not from vaccination because of a defect in antibody production. However, few studies have analyzed the titers of antibodies against HAV or HBV in IVIG products. In this study, the titers of anti-HAV and anti-HBs antibodies were measured in nineteen lots of IVIG products from five manufacturers from three countries (A, B from Korea; C, D from Japan; and E from the USA), and trough titers in plasma were estimated. Concentrations of anti-HAV antibody ranged from 1,888–8,927 mIU/mL and estimated trough titers exceeded the minimal protective value in all evaluated IVIG products. Concentrations of anti-HBs antibody ranged from 438–965 mIU/mL in products A and B and were 157, 123, and 1,945 mIU/mL in products C, D, and E, respectively. Estimated trough titers in products A, B, and E exceeded the minimal protective value but those in products C and D did not reach this threshold. These data demonstrated that available IVIG products generally provide sufficient antibodies against HAV and HBV to protect patients with PAD, although the trough concentrations of anti-HBs antibody in two IVIG products did not reach the minimum protective value.
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참고문헌 (39)
참고문헌 신청
Murphy TV / 2016 / Progress toward eliminating hepatitis A disease in the United States / MMWR Suppl 65:29~41
Ogholikhan S / 2016 / Hepatitis vaccines / Vaccines (Basel) 4:E6
Jacobsen KH / 2010 / Hepatitis A virus seroprevalence by age and world region, 1990 and 2005 / Vaccine 28:6653~6657
World Health Organization / Hepatitis A
Ciocca M / 2000 / Clinical course and consequences of hepatitis A infection / Vaccine 18(Suppl 1):S71~S74
Ogholikhan S / 2016 / Hepatitis vaccines / Vaccines (Basel) 4:E6
Jacobsen KH / 2010 / Hepatitis A virus seroprevalence by age and world region, 1990 and 2005 / Vaccine 28:6653~6657
World Health Organization / Hepatitis A
Ciocca M / 2000 / Clinical course and consequences of hepatitis A infection / Vaccine 18(Suppl 1):S71~S74
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