지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 510 - 518 (9page)
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The aim of this study was to identify the risk factors associated with severe bacterial infection (SBI) in multiple myeloma (MM) patients during treatment with bortezomibbased regimens. A total of 98 patients with MM were evaluated during 427 treatment courses. SBI occurred in 57.1% (56/98) of the patients and during 19.0% (81/427) of the treatment courses. In the multivariate analysis for the factors associated with the development of SBI in each treatment course, poor performance status (Eastern Cooperative Oncology Group ≥ 2, P < 0.001), early course of therapy (≤ 2 courses, P < 0.001), and pretreatment lymphopenia (absolute lymphocyte count < 1.0 × 109/L, P = 0.043) were confirmed as independent risk factors. The probability of developing SBI were 5.1%, 14.9%, 23.9%, and 59.5% in courses with 0, 1, 2, and 3 risk factors, respectively (P < 0.001). In conclusion, we identified three pretreatment risk factors associated with SBI in each course of bortezomib treatment. Therefore, MM patients with these risk factors should be more closely monitored for the development of SBI during bortezomib-based treatment.
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등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Augustson BM / 2005 / Early mortality after diagnosis of multiple myeloma : analysis of patients entered onto the United Kingdom Medical Research Council trials between 1980 and 2002--Medical Research Council Adult Leukaemia Working Party / J Clin Oncol 23:9219~9226
Blimark C / 2015 / Multiple myeloma and infections : a population-based study on 9253 multiple myeloma patients / Haematologica 100:107~113
Kuroki Y / 2007 / A study of innate immunity in patients with end-stage renal disease : special reference to toll-like receptor-2 and-4 expression in peripheral blood monocytes of hemodialysis patients / Int J Mol Med 19:783~790
Bodey GP / 1966 / Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia / Ann Intern Med 64:328~340
Bow EJ / 2013 / Infection in neutropenic patients with cancer / Crit Care Clin 29:411~441
Blimark C / 2015 / Multiple myeloma and infections : a population-based study on 9253 multiple myeloma patients / Haematologica 100:107~113
Kuroki Y / 2007 / A study of innate immunity in patients with end-stage renal disease : special reference to toll-like receptor-2 and-4 expression in peripheral blood monocytes of hemodialysis patients / Int J Mol Med 19:783~790
Bodey GP / 1966 / Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia / Ann Intern Med 64:328~340
Bow EJ / 2013 / Infection in neutropenic patients with cancer / Crit Care Clin 29:411~441
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