지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 영남대학교 의과대학 Journal of Yeungnam Medical Science Yeungnam University Journal of Medicine 제35권 제1호
- 발행연도
- 2018.1
- 수록면
- 76 - 83 (8page)
이용수
초록· 키워드
오류제보하기
Background: Elderly patients with multiple myeloma (MM) are vulnerable to adverse events (AEs). This study evaluated adherence to chemotherapy and treatment outcomes in elderly patients treated with a frontline bortezomib (BTZ), melphalan, and prednisone (VMP) regimen and regimens without BTZ. Methods: One-hundred and forty elderly patients who were diagnosed with MM from March 2007 to March 2015 were included in this retrospective study. To evaluate regimen adherence, patients who were treated with more than 4 cycles were assigned to the good adherence group. Results: Among the 140 patients, 71 were treated with a frontline VMP and 69 with non-BTZ regimens. The median age was 71 years (range, 65-90 years). The VMP group showed a higher complete response rate than the non-BTZ group: 26.8% vs. 7.2%. More patients in the VMP group achieved ≥very good partial response (VGPR) and ≥PR. In the VMP group, 27 patients (38.0%) received less than 4 cycles. The VMP good adherence group showed a higher 3-year overall survival (OS) rate (70.9%) than the poor adherence group (60.2%, p=0.059). In the multivariate analysis, treatment with ≥4 cycles of VMP was a favorable factor for OS. Conclusion: A good adherence to a frontline VMP regimen resulted in favorable long-term survival. Adequate management of AEs will be needed to achieve favorable outcomes in elderly patients with MM.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Gregory WM / 1992 / Combination chemotherapy versus melphalan and prednisolone in the treatment of multiple myeloma: an overview of published trials / J Clin Oncol 10:334~342
Palumbo A / 2006 / Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial / Lancet 367:825~831
Palumbo A / 2008 / Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial / Blood 112:3107~3114
San Miguel JF / 2008 / Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma / N Engl J Med 359:906~917
Palumbo A / 2012 / Continuous lenalidomide treatment for newly diagnosed multiple myeloma / N Engl J Med 366:1759~1769
Palumbo A / 2006 / Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trial / Lancet 367:825~831
Palumbo A / 2008 / Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial / Blood 112:3107~3114
San Miguel JF / 2008 / Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma / N Engl J Med 359:906~917
Palumbo A / 2012 / Continuous lenalidomide treatment for newly diagnosed multiple myeloma / N Engl J Med 366:1759~1769
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