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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 88 - 94 (7page)
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Purpose The present study aimed to re-stratify patients with high-risk prostate cancer according to the National Comprehensive Cancer Network guidelines among patients who underwent radical prostatectomy (RP). Materials and Methods This study used the Korean Prostate Cancer Database registry and identified 1,060 patients with high-risk prostate cancer who underwent RP between May 2001 and April 2013. All patients were categorized into risk groups, and subgroups were identified according to the type and number of high-risk factors. Results Of the 1,060 high-risk patients, 599 (56.5%), 408 (38.5%), and 53 (5.0%) had 1, 2, and 3 risk factors, respectively. In multivariate analysis, the Gleason score, percentage of positive biopsy cores, and number of risk factors present were identified as independent predictors of biochemical recurrence. There were significant differences in the 5-year postoperative biochemical failure-free survival (BCFFS) rate among the different high-risk factor subgroups (log-rank p < 0.001). There were no significant differences in the BCFFS rate between the subgroup of high-risk patients with a prostate-specific antigen level > 20 ng/mL alone and the intermediate-risk group with all factors (log-rank p=0.919 and p=0.781, respectively). Additionally, no significant difference was noted in the BCFFS rate between high-risk patients having all factors and those in the very-high-risk group (p=0.566). Conclusion We successfully re-stratified patients with high-risk prostate cancer and identified the combinations of high-risk criteria that will help in the selection of patients for RP.
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참고문헌 (25)
참고문헌 신청
Heidenreich A / 2014 / EAU guidelines on prostate cancer. part 1: screening, diagnosis, and local treatment with curative intentupdate 2013 / Eur Urol 65:124~137
2013 / Cancer statistics / JAMA 310:982
Chung BH / 2013 / The role of radical prostatectomy in high-risk prostate cancer / Prostate Int 1:95~101
오창모 / 2016 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2013 / Cancer Research and Treatment 48(2):436~450
Carter HB / 2013 / Early detection of prostate cancer: AUA guideline / J Urol 190:419~426
2013 / Cancer statistics / JAMA 310:982
Chung BH / 2013 / The role of radical prostatectomy in high-risk prostate cancer / Prostate Int 1:95~101
오창모 / 2016 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2013 / Cancer Research and Treatment 48(2):436~450
Carter HB / 2013 / Early detection of prostate cancer: AUA guideline / J Urol 190:419~426
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