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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 340 - 347 (8page)
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Rheumatoid arthritis (RA) is an autoimmune disease that starts with decreased tolerance to modified self-antigens and eventually leads to synovitis and destruction of bone and cartilage. Age is a risk factor for developing RA. Major changes in the immune system come with age due to chronic oxidative stress on the deoxyribonucleic acid (DNA) damage pathway, somatic mutation, modifications of auto-antigens, T cell tolerance and activation of fibroblast-like synoviocytes (FLS). Reactive oxygen species (ROS) generated by nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2) suppress T cell receptor signaling. Sirtuin 1 (SIRT1) is a critical immune suppressor of T cell activation and a key regulator of oxidative stress. When oxidative stress reduces activity of SIRT1, the breakdown of tolerance to modified self-antigens is expected. Generation of ROS can be perpetuated by enhanced DNA damage and dysfunctional mitochondria in a feedback loop during the development of RA. Through major T cell loss and selective proliferation of peripheral T cells, pro-inflammatory T cell pools with abnormal features are established in the T cell compartment. Hypoxic and inflammatory condition in synovium perpetuates ROS generation, which leads to the activation of FLS. In both T cell and synovium compartment, oxidative stress reshapes the immune system into the development of pre-clinical RA. (J Rheum Dis 2016;23:340-347)
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참고문헌 (69)
참고문헌 신청
Williams MS / 2004 / T cell receptor stimulation, reactive oxygen species, and cell signaling / Free Radic Biol Med 37:1144~1151
Holmström KM / 2014 / Cellular mechanisms and physiological consequences of redox-dependent signalling / Nat Rev Mol Cell Biol 15:411~421
Lambeth JD / 2014 / Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited / Annu Rev Pathol 9:119~145
McInnes IB / 2011 / The pathogenesis of rheumatoid arthritis / N Engl J Med 365:2205~2219
Filippin LI / 2008 / Redox signalling and the inflammatory response in rheumatoid arthritis / Clin Exp Immunol 152:415~422
Holmström KM / 2014 / Cellular mechanisms and physiological consequences of redox-dependent signalling / Nat Rev Mol Cell Biol 15:411~421
Lambeth JD / 2014 / Nox enzymes and new thinking on reactive oxygen: a double-edged sword revisited / Annu Rev Pathol 9:119~145
McInnes IB / 2011 / The pathogenesis of rheumatoid arthritis / N Engl J Med 365:2205~2219
Filippin LI / 2008 / Redox signalling and the inflammatory response in rheumatoid arthritis / Clin Exp Immunol 152:415~422
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