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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 44 - 51 (8page)
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초록· 키워드
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Dendritic cells (DCs) are professional antigen presenting cells, and play an important role in the induction of antigen-specific adaptive immunity. However, some DC populations are involved in immune regulation and immune tolerance. These DC populations are believed to take part in the control of immune exaggeration and immune disorder, and maintain immune homeostasis in the body. Tolerogenic DCs (tolDCs) can be generated in vitro by genetic or pharmacological modification or by controlling the maturation stages of cytokine-derived DCs. These tolDCs have been investigated for the treatment of rheumatoid arthritis (RA) in experimental animal models. In the last decade, several in vitro and in vivo approaches have been translated into clinical trials. As of 2015, three tolDC trials for RA are on the list of ClinicalTrial.gov (www.clinicaltrials.gov). Other trials for RA are in progress and will be listed soon. In this review, we discuss the evolution of tolDC-based immunotherapy for RA and its limitations and future prospects.
목차
INTRODUCTION
GENERATION OF tolDCs
ROLES OF tolDCs IN THE IMMUNE SYSTEM
TolDCs AND AUTOIMMUNITY
TolDC IMMUNOTHERAPY IN CIA MICE
CLINICAL TRIALS OF tolDC IMMUNOTHERAPY FOR PATIENTS WITH RA
LIMITATIONS OF tolDC-based RA IMMUNOTHERAPY
FUTURE PROSPECTS OF tolDC-based RA IMMUNOTHERAPY
REFERENCES
참고문헌 (69)
참고문헌 신청
Hilkens, C. M., and J. D. Isaacs. 2013. Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now? Clin. Exp. Immunol. 172: 148-157.
Choy, E. H., A. F. Kavanaugh, and S. A. Jones. 2013. The problem of choice: current biologic agents and future prospects in RA. Nat. Rev. Rheumatol. 9: 154-163.
Singh, J. A., R. Christensen, G. A. Wells, M. E. Suarez-Almazor, R. Buchbinder, M. A. Lopez-Olivo, G. E. Tanjong, and P. Tugwell. 2009. Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst. Rev. CD007848.
Stoop, J. N., J. H. Robinson, and C. M. Hilkens. 2011. Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models? Ann. Rheum. Dis. 70: 1526-1533.
Steinman, R. M. 2012. Decisions about dendritic cells: past, present, and future. Annu. Rev. Immunol. 30: 1-22.
Choy, E. H., A. F. Kavanaugh, and S. A. Jones. 2013. The problem of choice: current biologic agents and future prospects in RA. Nat. Rev. Rheumatol. 9: 154-163.
Singh, J. A., R. Christensen, G. A. Wells, M. E. Suarez-Almazor, R. Buchbinder, M. A. Lopez-Olivo, G. E. Tanjong, and P. Tugwell. 2009. Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Cochrane Database Syst. Rev. CD007848.
Stoop, J. N., J. H. Robinson, and C. M. Hilkens. 2011. Developing tolerogenic dendritic cell therapy for rheumatoid arthritis: what can we learn from mouse models? Ann. Rheum. Dis. 70: 1526-1533.
Steinman, R. M. 2012. Decisions about dendritic cells: past, present, and future. Annu. Rev. Immunol. 30: 1-22.
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