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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.8 No.1
- 발행연도
- 2016.1
- 수록면
- 63 - 68 (6page)
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Purpose: Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with markedly increased eosinophils, Th2-type lymphocytes, fibroblasts, and goblet cells. Fungi are commonly associated with airway inflammatory diseases, and thymic stromal lymphopoietin (TSLP) is important in the development of Th2 inflammatory responses. The aim of this study was to investigate the interaction between airborne fungi and nasal fibroblasts in TSLP mRNA and protein expression. Methods: Inferior turbinate and nasal polyp fibroblasts were stimulated with Alternaria and Aspergillus, respectively, for 48 hours, and TSLP mRNA and protein expressions were measured. The reverse transcriptase polymerase chain reaction was performed for the Toll-like receptor (TLR) mRNA expression of the nasal fibroblasts. To determine the role of TLR in the induction of TSLP, the fibroblasts were transfected with siRNA against TLR2 and TLR5. Results: Alternaria induced TSLP mRNA and protein expression in both inferior turbinate and nasal polyp fibroblasts. The nasal polyp fibroblasts responded more strongly to the fungi. TLR2 and TLR5 mRNA expressions were significantly increased with fungal stimulation and TSLP production was significantly inhibited by siRNA against TLR2. Conclusions: The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especially in CRS with nasal polyps.
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참고문헌 (18)
참고문헌 신청
Zhang K / 2007 / Constitutive and inducible thymic stromal lymphopoietin expression in human airway smooth muscle cells: role in chronic obstructive pulmonary disease / Am J Physiol Lung Cell Mol Physiol 293:L375~L382
Ziegler SF / 2010 / The role of thymic stromal lymphopoietin (TSLP) in allergic disorders / Curr Opin Immunol 22:795~799
Liu YJ. / 2006 / Thymic stromal lymphopoietin: master switch for allergic inflammation / J Exp Med 203:269~273
Ying S / 2008 / Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease / J Immunol 181:2790~2798
Satoko Kimura / 2011 / Increased Expression and Role of Thymic Stromal Lymphopoietin in Nasal Polyposis / Allergy, Asthma & Immunology Research 3(3):186~193
Ziegler SF / 2010 / The role of thymic stromal lymphopoietin (TSLP) in allergic disorders / Curr Opin Immunol 22:795~799
Liu YJ. / 2006 / Thymic stromal lymphopoietin: master switch for allergic inflammation / J Exp Med 203:269~273
Ying S / 2008 / Expression and cellular provenance of thymic stromal lymphopoietin and chemokines in patients with severe asthma and chronic obstructive pulmonary disease / J Immunol 181:2790~2798
Satoko Kimura / 2011 / Increased Expression and Role of Thymic Stromal Lymphopoietin in Nasal Polyposis / Allergy, Asthma & Immunology Research 3(3):186~193
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