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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 481 - 486 (6page)
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초록· 키워드
오류제보하기
Cosmetics are primarily applied to the skin; therefore, the association of cosmetic dyes with skin diseases or inflammation is a topic of great interest. Thymic stromal lymphopoietin (TSLP) is an interleukin 7-like cytokine that activates dendritic cells to promote Th2 inflammatory immune responses. TSLP is highly expressed in keratinocytes under inflammatory conditions, which suggests that it may play a critical role in the development of skin diseases, such as atopic dermatitis. Therefore, we investigated whether cosmetic dyes influenced the production of TSLP by keratinocytes. Phloxine O, also known as D&C Red No.27, is one of the most common red synthetic pigments and is widely used in colored cosmetics. Our results showed that Phloxine O downregulated phorbol 12-myristate 13-acetate-induced production of TSLP in a murine keratinocyte cell line (PAM212). Phloxine O also suppressed TSLP expression in KCMH-1 cells, which are mouse keratinocytes that constitutively produce high levels of TSLP. To investigate the in vivo effects of Phloxine O, we induced TSLP expression in mouse ear skin by topically applying MC903, a vitamin D3 analogue that is a well-known inducer of atopic dermatitis-like symptoms. Topical application of Phloxine O prevented MC903-induced TSLP production in mouse ear skin, attenuated the acute dermatitis-like symptoms and decreased serum IgE and histamine levels in mice. Suppression of TSLP expression by Phloxine O correlated with reduced expression of OX40 ligand and Th2 cytokines in mouse ear skin. Our results showed that Phloxine O may be beneficial to prevent dermatitis by suppressing the expression of TSLP and Th2 cytokines in skin.
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참고문헌 (29)
참고문헌 신청
Allakhverdi, Z. / 2011 / Dexamethasone regulation of thymic stromal lymphopoietin receptor expression on mast cells and their precursors / J. Allergy Clin. Immunol. 127:523~524
Bieber, T. / 2008 / Atopic dermatitis / N. Engl. J. Med. 358:1483~1494
Brown, S. J. / 2008 / Filaggrin null mutations and childhood atopic eczema: a population-based case-control study / J. Allergy Clin. Immunol. 121:940~946
Cianferoni, A. / 2014 / The importance of TSLP in allergic disease and its role as a potential therapeutic target / Expert Rev. Clin. Immunol. 10:1463~1474
Cultrone, A. / 2013 / The NF-${\kappa}B$ binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells / Eur. J. Immunol. 43:1053~1062
Bieber, T. / 2008 / Atopic dermatitis / N. Engl. J. Med. 358:1483~1494
Brown, S. J. / 2008 / Filaggrin null mutations and childhood atopic eczema: a population-based case-control study / J. Allergy Clin. Immunol. 121:940~946
Cianferoni, A. / 2014 / The importance of TSLP in allergic disease and its role as a potential therapeutic target / Expert Rev. Clin. Immunol. 10:1463~1474
Cultrone, A. / 2013 / The NF-
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