지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.3 No.3
- 발행연도
- 2011.1
- 수록면
- 186 - 193 (8page)
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Purpose: Nasal polyposis is a chronic inflammatory disease of the upper airways often associated with asthma and characterized by markedly increased numbers of eosinophils, Th2 type lymphocytes, fibroblasts, goblet cells and mast cells. Previous studies have shown elevated levels of thymic stromal lymphopoietin (TSLP) in atopic diseases like asthma, atopic dermatitis and mainly in animal models of allergic rhinitis (AR). Here, we investigated the expression of TSLP in nasal polyps from atopics and non-atopics in comparison with the nasal mucosa and its potential role in nasal polyposis. Methods: Messenger RNA expression for TSLP, thymus and activation-regulated chemokine (TARC) and macrophage derived chemokine (MDC) in nasal polyps and nasal mucosa of atopics and non-atopics was analyzed by real time PCR. Immunoreactivity for TSLP in nasal polyps and in the nasal mucosa of patients with AR and non-allergic rhinitis (NAR) was analyzed by immunohistochemistry. Eosinophil counts was analyzed by Wright-Giemsa staining and nasal polyp tissue IgE, by ELISA. Results: Messenger RNA expression for TSLP,TARC and MDC was markedly higher in nasal polyps as compared to the allergic nasal mucosa. Immunoreactivity for TSLP was detected in epithelial cells, endothelial cells, fibroblasts and inflammatory cells of the nasal mucosa and nasal polyps. The number of TSLP+ cells was significantly greater in the nasal mucosa of AR than NAR patients. The number of TSLP+ cells in nasal polyps from atopics was significantly greater than that of non-atopics and that in the allergic nasal mucosa. The number of TSLP+ cells correlated well with the number of eosinophils and the levels of IgE in nasal polyps. Conclusions: The high expression of TSLP in nasal polyps and its strong correlation to eosinophils and IgE suggest a potential role for TSLP in the pathogenesis of nasal polyps by regulating the Th2 type and eosinophilic inflammation.
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참고문헌 (35)
참고문헌 신청
Hamilos DL / 1995 / Evidence for distinct cytokine expression in allergic versus nonallergic chronic sinusitis / J Allergy Clin Immunol 96:537~544
Pawankar R / 2003 / Nasal polyposis: an update: editorial review / Curr Opin Allergy Clin Immunol 3:1~6
Pawankar R / 2007 / Role of mast cells and basophils in chronic rhinosinusitis / Clin Allergy Immunol 20:93~101
Fan GK / 2007 / Eosinophil infiltration and activation in nasal polyposis / Acta Otolaryngol 127:521~526
Nonaka M / 2010 / Combined stimulation with Poly(I:C), TNF-alpha and Th2 cytokines induces TARC production by human fibroblasts from the nose, bronchioles and lungs / Int Arch Allergy Immunol 152:327~341
Pawankar R / 2003 / Nasal polyposis: an update: editorial review / Curr Opin Allergy Clin Immunol 3:1~6
Pawankar R / 2007 / Role of mast cells and basophils in chronic rhinosinusitis / Clin Allergy Immunol 20:93~101
Fan GK / 2007 / Eosinophil infiltration and activation in nasal polyposis / Acta Otolaryngol 127:521~526
Nonaka M / 2010 / Combined stimulation with Poly(I:C), TNF-alpha and Th2 cytokines induces TARC production by human fibroblasts from the nose, bronchioles and lungs / Int Arch Allergy Immunol 152:327~341
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