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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
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- 1 - 13 (13page)
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TLR signaling is critical for broad scale immune recognition of pathogens and/or danger molecules. TLRs are particularly important for the activation and the maturation of cells comprising the innate immune response. In recent years it has become apparent that several different TLRs regulate the function of lymphocytes as well, albeit to a lesser degree compared to innate immunity. TLR2 heterodimerizes with either TLR1 or TLR6 to broadly recognize bacterial lipopeptides as well as several danger-associated molecular patterns. In general, TLR2 signaling promotes immune cell activation leading to tissue inflammation, which is advantageous for combating an infection. Conversely, inappropriate or dysfunctional TLR2 signaling leading to an overactive inflammatory response could be detrimental during sterile inflammation and autoimmune disease. This review will highlight and discuss recent research advances linking TLR2 engagement to autoimmune inflammation.
목차
ABSTRACT
INTRODUCTION
TLR2 EXPRESSION AND LIGATION
LOSS OF TLR2 SIGNALING IN MODELS OF AUTOIMMUNE INFLAMMATION AND HUMAN CORRELATIONS
INNATE ROLES OF TLR2 IN DRIVING AUTOIMMUNE INFLAMMATION
INTRINSIC TLR2 SIGNALING IN B CELL AND T CELLS CONTRIBUTES TO AUTOIMMUNE DISEASE PATHOGENESIS
CONCLUDING REMARKS
REFERENCES
참고문헌 (80)
참고문헌 신청
Davidson A / 2001 / Autoimmune diseases / N Engl J Med 345:340~350
Cooper GS / 2003 / The epidemiology of autoimmune diseases / Autoimmun Rev 2:119~125
Jadidi-Niaragh F / 2011 / Th17 cell, the new player of neuroinflammatory process in multiple sclerosis / Scand J Immunol 74:1~13
Yasuda K / 2019 / The pathogenicity of Th17 cells in autoimmune diseases / Semin Immunopathol 41:283~297
Thomas SL / 2010 / Burden of mortality associated with autoimmune diseases among females in the United Kingdom / Am J Public Health 100:2279~2287
Cooper GS / 2003 / The epidemiology of autoimmune diseases / Autoimmun Rev 2:119~125
Jadidi-Niaragh F / 2011 / Th17 cell, the new player of neuroinflammatory process in multiple sclerosis / Scand J Immunol 74:1~13
Yasuda K / 2019 / The pathogenicity of Th17 cells in autoimmune diseases / Semin Immunopathol 41:283~297
Thomas SL / 2010 / Burden of mortality associated with autoimmune diseases among females in the United Kingdom / Am J Public Health 100:2279~2287
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UCI(KEPA) : I410-ECN-0101-2021-517-001845503