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학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

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논문 기본 정보

자료유형
학술저널
저자정보
장원석 (연세대학교) 장진우 (연세대학교)
저널정보
대한의용생체공학회 Biomedical Engineering Letters (BMEL) Biomedical Engineering Letters (BMEL) Vol.7 No.2
발행연도
2017.1
수록면
107 - 114 (8page)

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The concept of focused ultrasound (FUS) and itsapplication in the field of medicine have been suggestedsince the mid-20th century. However, the clinical applicationsof this technique in central nervous system (CNS)diseases have been extremely limited because the skullinhibits efficient energy transmission. Therefore, earlyapplication of FUS treatment was only performed inpatients who had already undergone invasive proceduresincluding craniectomy and burr hole trephination. In the1990s, the phased array technique was developed and thisenabled the focus of ultrasonic energy through the skull,and in conjunction with another technique, magnetic resonancethermal monitoring, the possibility of applying FUSin the CNS was further strengthened. The first clinical trialusing FUS treatment for CNS diseases was performed inthe early 21st century in patients with glioblastoma, whichconsists of highly malignant primary brain tumors. However,this trial resulted in a failure to make lesions in thetumors. Various causes were suggested for this outcomeincluding different acoustic impedances across heterogeneousintracranial tissue (not only brain tissue, but alsofibrous or tumor tissue). To avoid the influence of thisfactor, the targets for FUS treatment were shifted tofunctional diseases such as essential tremor, Parkinson’sdisease, and psychiatric disease, which usually occur innormal brain structures. The first trial for functional diseaseswas started in 2010, and the results were successfulas accurate lesions were made in the target area. Nowadays, the indication of FUS treatment for functionalCNS diseases is gradually widening, and many trials usingthe FUS technique are reporting good results. In addition tothe lesioning technique using high intensity FUS treatment,the possibility of clinical application of low intensity FUSto CNS disease treatment has been investigated at a preclinicallevel, and it is expected that FUS treatment willbecome one of the most important novel techniques for thetreatment of CNS diseases in the near future.

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참고문헌 (36)

참고문헌 신청
Heimburger RF / 1958 / Report of the first international congress of neurological sciences, Brussels, Belgium, July 21–27, 1957 / J Neurosurg 15(3):342~351 google schola Lasak JM / 2009 / The history of stereotactic radiosurgery and radiotherapy / Otolaryngol Clin N Am 42(4):593~599 google schola Lynn JG / 1944 / Histology of cerebral lesions produced by focused ultrasound / Am J Pathol 20(3):637~649 google schola Guthkelch A / 1991 / Treatment of malignant brain tumors with focused ultrasound hyperthermia and radiation : results of a phase I trial / J Neurooncol 10(3):271~284 google schola Kenneth BO / 1984 / An ultrasonic phased array applicator for hyperthermia / IEEE 31(5):527~531 google schola

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