지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 88 - 93 (6page)
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Purpose: Propiverine hydrochloride (PH) is widely used for the treatment of urinary incontinence (UI) due to bladder overactivity. Moreover, the comorbidity of UI with fecal incontinence (FI) is known to be due to the relationship of both to nervous system disorders and dysfunction or weakening of the pelvic floor muscles. The aim of this single-arm prospective study was to evaluate the therapeutic value of PH for FI. Methods: Patients (n = 24) who were diagnosed as having both FI and UI from April 2015 to November 2016 were included in the study and administered a dosage of 10–20 mg PH every day for 1 month. The primary endpoint was to create a reduction in the frequency of FI per week. An evaluation criterion of ≥50% reduction in frequency was determined as effective. The percentage of the patients who achieved the ≥50% endpoint (responders) was also calculated. Results: The frequency of FI per week was 6.0 ± 8.2 (0.25–30) at baseline and reduced to 1.6 ± 2.1 (0–7) at the posttherapeutic state (P = 0.005). A reduction of ≥50% was seen in 14 of the patients (58.3%). Conclusion: PH reduced the frequency of FI in patients with both FI and UI. This study introduces a possible therapeutic option for the pharmacological treatment of FI.
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등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Norton C / 2010 / Management of fecal incontinence in adults / Neurourol Urodyn 29:199~206
Paquette IM / 2015 / The American Society of Colon and Rectal Surgeons’ Clinical Practice Guideline for the treatment of fecal incontinence / Dis Colon Rectum 58:623~636
Haruno A / 1989 / Effects of propiverine hydrochloride and its metabolites on isolated guinea pig urinary bladder / Nihon Yakurigaku Zasshi 94:145~150
Nomura N / 1989 / Effects of propiverine hydrochloride(P-4)and its metabolites on urinary bladder function in anesthetized rats / Nihon Yakurigaku Zasshi 94:173~180
Rockwood TH / 1999 / Patient and surgeon ranking of the severity of symptoms associated with fecal incontinence : the fecal incontinence severity index / Dis Colon Rectum 42:1525~1532
Paquette IM / 2015 / The American Society of Colon and Rectal Surgeons’ Clinical Practice Guideline for the treatment of fecal incontinence / Dis Colon Rectum 58:623~636
Haruno A / 1989 / Effects of propiverine hydrochloride and its metabolites on isolated guinea pig urinary bladder / Nihon Yakurigaku Zasshi 94:145~150
Nomura N / 1989 / Effects of propiverine hydrochloride(P-4)and its metabolites on urinary bladder function in anesthetized rats / Nihon Yakurigaku Zasshi 94:173~180
Rockwood TH / 1999 / Patient and surgeon ranking of the severity of symptoms associated with fecal incontinence : the fecal incontinence severity index / Dis Colon Rectum 42:1525~1532
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