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논문 기본 정보

자료유형
학술저널
저자정보
Minsu Kim (Konkuk University) Hyejung Mok (Konkuk University) Woon-Seok Yeo (Konkuk University) Joong-Hoon Ahn (Konkuk University) Yoon Kyung Choi (Konkuk University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.45 No.5
발행연도
2021.9
수록면
599 - 609 (11page)

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초록· 키워드

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Ginseng has long been considered as an herbal medicine. Recent data suggest that ginseng has anti-inflammatory properties and can improve learning- and memory-related function in the central nervous system (CNS) following the development of CNS neuroinflammatory diseases such as Alzheimer’s disease, cerebral ischemia, and other neurological disorders. In this review, we discuss the role of ginseng in the neurovascular unit, which is composed of endothelial cells surrounded by astrocytes, pericytes, microglia, neural stem cells, oligodendrocytes, and neurons, especially their blood-brain barrier maintenance, anti-inflammatory effects and regenerative functions. In addition, cell-cell communication enhanced by ginseng may be attributed to regeneration via induction of neurogenesis and angiogenesis in CNS diseases. Thus, ginseng may have therapeutic potential to exert cognitive improvement in neuroinflammatory diseases such as stroke, traumatic brain injury, multiple sclerosis, Parkinson’s disease, and Alzheimer’s disease.

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abstract
1. Introduction
2. Role of ginseng in the CNS repair processing
3. Functions of ginseng in various cell types in neurovascular unit
4. Role of ginseng/ginsenosides in neuroinflammatory diseases
5. Clinical trials in human study
6. Perspectives
References

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