Protective and Therapeutic Effects of Aloe Vera Gel on Ulcerative Colitis Induced by Acetic Acid in Rats

Gholamreza Bahrami; Hossein Malekshahi; Shahram Miraghaee; Hamid Madani; Atefeh Babaei; Bahareh Mohammadi; Razieh Hatami

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자료유형: 학술저널

저자정보: Gholamreza Bahrami (Kermanshah University of Medical Sciences) Hossein Malekshahi (Kermanshah University of Medical Sciences) Shahram Miraghaee (Kermanshah University of Medical Sciences) Hamid Madani (Kermanshah University of Medical Sciences) Atefeh Babaei (Kermanshah University of Medical Sciences) Bahareh Mohammadi (Kermanshah University of Medical Sciences) Razieh Hatami (Kermanshah University of Medical Sciences)

저널정보: 한국임상영양학회 Clinical Nutrition Research Clinical Nutrition Research Vol.9 No.3

발행연도: 2020.1

수록면: 223 - 234 (12page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

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Ulcerative colitis (UC) is a chronic intestinal inflammation. Common clinical symptoms are weight loss, diarrhea, ulcers, and inflammation. Aloe vera (AV) has several medicinal properties including antioxidant, anti-inflammatory analgesic, and improvement of gastric and skin ulcers. This study aimed to investigate the protective and therapeutic effects of AV gel on acetic acid-induced UC in rats. UC was induced in 48 rats by injection of 4% acetic acid into the rectum. Protective and treatment groups received treatments 7 days before and after the induction of colitis, respectively. The negative control group, the positive control group, and AV groups received distilled water, sulfasalazine, and 50 and 300 mg/kg of gel extract, respectively. Water and food intake and body weight changes were recorded. The extent of the mucosal ulcers, colon tissue thickening, and mucosal bleeding were scored by the Gerald classification system score (microscopy observations). Slides of tissues were prepared for pathologic assay using the modified Wallace method (macroscopic observations). The results of the macroscopic and microscopic examination showed protective and therapeutic effects of 50 mg/kg dose of AV on acetic acid-induced colitis in rats which reduces the inflammation, ulcers and tissue damage compared with negative control (p < 0.05). There were no significant changes in the amount of water and food intake, body weight changes, and colon weight in protective and treatment groups. Based on the results, AV gel could be used to improve the symptoms of UC, as well as prevent people who are susceptible to the UC.

#Ulcerative colitis #Aloe vera gel #Inflammation #Fibrosis #Rat

참고문헌 (37)

참고문헌 신청

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