메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Ma Mingyue (Agronomy of Food Science and Technology, Yanbian University, Yanji 133002, Jilin, P.R. ChinaInstitute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural R) Li Yueqiao (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) He Yuguang (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) Li Da (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) Niu Honghong (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) Sun Mubai (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) Miao Xinyu (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) Su Ying (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) Zhang Hua (Agronomy of Food Science and Technology, Yanbian University, Yanji 133002, Jilin, P.R. China) Hua Mei (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China) Wang Jinghui (Institute of Agro-product Process, Jilin Academy of Agricultural Science (Northeast Agricultural Research Center of China), Changchun 130033, Jilin, P.R. China)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.6
발행연도
2024.6
수록면
1,287 - 1,298 (12page)
DOI
10.4014/jmb.2402.02027

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) that is currently difficult to treat effectively. Both Bacillus natto (BN) and ginseng-soluble dietary fiber (GSDF) are anti-inflammatory and helps sustain the intestinal barrier. In this study, the protective effects and mechanism of the combination of B. natto JLCC513 and ginseng-soluble dietary fiber (BG) in DSS-induced UC mice were investigated. Intervention with BG worked better than taking BN or GSDF separately, as evidenced by improved disease activity index, colon length, and colon injury and significantly reduced the levels of oxidative and inflammatory factors (LPS, ILs, and TNF-α) in UC mice. Further mechanistic study revealed that BG protected the intestinal barrier integrity by maintaining the tight junction proteins (Occludin and Claudin1) and inhibited the LPS/TLR4/NF-κB pathway in UC mice. In addition, BG increased the abundance of beneficial bacteria such as Bacteroides and Turicibacter and reduced the abundance of harmful bacteria such as Allobaculum in the gut microbiota of UC mice. BG also significantly upregulated genes related to linoleic acid metabolism in the gut microbiota. These BGinduced changes in the gut microbiota of mice with UC were significantly correlated with changes in pathological indices. In conclusion, this study demonstrated that BG exerts protective effect against UC by regulating the LPS/TLR4/NF-κB pathway and the structure and metabolic function of gut microbiota. Thus, BG can be potentially used in intestinal health foods to treat UC.

목차

등록된 정보가 없습니다.

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

최근 본 자료

전체보기

댓글(0)

0