지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 353 - 358 (6page)
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초록· 키워드
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The γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system. The π subunit receptor of GABA (GABRP) is a transmembrane multi-subunit chloride channel that is expressed in the CNS and several other non-neuronal tissues. The exact function of this gene in non-neuronal tissues is not clearly identified. Our previous customized pilot SNPs chip screens analysis indicated that this gene had strong susceptibility to ulcerative colitis (UC). This study was aimed to validate whether the polymorphisms in the GABRP gene are associated with the susceptibility to UC. The genotype and allele frequencies of the rs929763 rs1063310, rs3805455, rs382819 and rs732157 of the GABRP gene were significantly associated with UC patients. Two haplotype frequencies including a major haplotype of GABRP SNPs were more significantly different between the UC patients and the healthy controls. These results suggest that the polymorphisms in the GABRP gene might be associated with the susceptibility to UC, and the haplotype of GABRP SNPs are useful genetic marker for UC.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bouma G / 2003 / The immunological and genetic basis of inflammatory bowel disease / Nat Rev Immunol 3:521~533
Cosnes J / 2011 / Epidemiology and natural history of inflammatory bowel diseases / Gastroenterology 140:1785~1794
Fiocchi C / 2012 / IBD: advances in pathogenesis, complications, diagnosis, and therapy / Curr Opin Gastroenterol 28:297~300
Fiocchi C / 2015 / Inflammatory bowel disease pathogenesis: where are we? / J Gastroenterol Hepatol 30(Suppl 1):12~18
Gersemann M / 2011 / From intestinal stem cells to inflammatory bowel diseases / World J Gastroenterol 17:3198~3203
Cosnes J / 2011 / Epidemiology and natural history of inflammatory bowel diseases / Gastroenterology 140:1785~1794
Fiocchi C / 2012 / IBD: advances in pathogenesis, complications, diagnosis, and therapy / Curr Opin Gastroenterol 28:297~300
Fiocchi C / 2015 / Inflammatory bowel disease pathogenesis: where are we? / J Gastroenterol Hepatol 30(Suppl 1):12~18
Gersemann M / 2011 / From intestinal stem cells to inflammatory bowel diseases / World J Gastroenterol 17:3198~3203
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