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Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease
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Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease

논문 기본 정보

자료유형
학술저널
저자정보
Meng-Tzu Weng (National Taiwan University Hospital) I-Lun Shih (National Taiwan University Hospital and College of Medicine) Chien-Chih Tung (National Taiwan University Hospital and College of Medicine) Yew-Loong Leong (National Taiwan University Hospital) Ming-Jium Shieh (National Taiwan University Hospital)
저널정보
대한장연구학회 Intestinal research Intestinal research Vol.20 No.2 KCI Accredited Journals
발행연도
2022.4
수록면
224 - 230 (7page)
DOI
10.5217/ir.2021.00042

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Association of young age and male sex with primary sclerosing cholangitis in Taiwanese patients with inflammatory bowel disease
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Background/Aims: Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). We aimed to evaluate the prevalence, clinical manifestation, and outcomes of PSC in Taiwanese patients with IBD. Methods: This retrospective study enrolled patients with IBD admitted from January 1, 1996, to December 31, 2018, to National Taiwan University Hospital. A case-matched analysis was performed comparing patients with IBD with and without PSC according to age, sex, and time of admission, with ratios of 1:4 and 1:2 in the adult and pediatric groups, respectively. Results: In total, 763 patients with IBD were enrolled, 12 of whom were also diagnosed with PSC (1.57%). All these patients had ulcerative colitis (UC). A greater incidence of IBD with PSC was observed in younger patients than in older patients. Male sex was a risk factor for PSC in pediatric patients with IBD (P=0.015); 75% of these patients were diagnosed with PSC along with or after the diagnosis of UC. There was no significant difference in colitis extent and severity between the groups; however, a higher proportion of rectal sparing was observed in patients with PSC (P=0.001). There was no significant difference in cancer development between the groups (P=0.679). Conclusions: A 1.57% prevalence of PSC was observed in Taiwanese patients with IBD. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Hence, routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD.

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