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논문 기본 정보
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- 학술저널
- 저자정보
- 발행연도
- 2021.1
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Primary biliary cholangitis (PBC) causes chronic and persistent cholestasis in the liver, eventually resulting in cirrhosis and hepatic failure without appropriate treatment. PBC mainly develops in middle-aged women, but it is also common in young women and men. PBC is considered a model of autoimmune disease because of the presence of diseasespecific autoantibodies, that is, antimitochondrial antibodies (AMAs), intense infiltration of mononuclear cells into the bile ducts, and a high prevalence of autoimmune diseases such as comorbidities. Histologically, PBC is characterized by degeneration and necrosis of intrahepatic biliary epithelial cells surrounded by a dense infiltration of mononuclear cells, coined as chronic non-suppurative destructive cholangitis, which leads to destructive changes and the disappearance of small- or medium-sized bile ducts. Since 1990, early diagnosis with the detection of AMAs and introduction of ursodeoxycholic acid as first-line treatment has greatly altered the clinical course of PBC, and liver transplantation-free survival of patients with PBC is now comparable to that of the general population.
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참고문헌 (171)
참고문헌 신청
Addison T / 1851 / On a certain affection of the skin-vitiligoideaalpha-plana, B-tuberosa / Guys Hosp Rep 7:265~276
Dauphinee JA / 1949 / Primary biliary cirrhosis / Can Med Assoc J 61:1~6
Beuers U / 2015 / Changing nomenclature for PBC: from ‘cirrhosis’ to ‘cholangitis’ / Clin Res Hepatol Gastroenterol 39:e57~e59
Beuers U / 2015 / Changing nomenclature for PBC: from ‘cirrhosis’ to ‘cholangitis’ / Dig Liver Dis 47:924~926
Beuers U / 2015 / Changing nomenclature for PBC: from ‘cirrhosis’ to ‘cholangitis’ / Am J Gastroenterol 110:1536~1538
Dauphinee JA / 1949 / Primary biliary cirrhosis / Can Med Assoc J 61:1~6
Beuers U / 2015 / Changing nomenclature for PBC: from ‘cirrhosis’ to ‘cholangitis’ / Clin Res Hepatol Gastroenterol 39:e57~e59
Beuers U / 2015 / Changing nomenclature for PBC: from ‘cirrhosis’ to ‘cholangitis’ / Dig Liver Dis 47:924~926
Beuers U / 2015 / Changing nomenclature for PBC: from ‘cirrhosis’ to ‘cholangitis’ / Am J Gastroenterol 110:1536~1538
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