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논문 기본 정보

자료유형
학술저널
저자정보
Ji Hyun Kim (Department of Pediatrics Busan Paik Hospital Inje University College of Medicine Busan Korea) Ji Yeon Lee (Department of Pediatrics Busan Paik Hospital Inje University College of Medicine Busan Korea) Bo Lyun Lee (Department of Pediatrics Busan Paik Hospital Inje University College of Medicine Busan Korea) Kwang Hoon Kim (Department of Pediatrics Busan Paik Hospital Inje University College of Medicine Busan Korea) Jeong Eun Lee (Department of Pediatrics Busan Paik Hospital Inje University College of Medicine Busan Korea) Ji Kyoung Park (Department of Pediatrics Busan Paik Hospital Inje University College of Medicine Busan Korea)
저널정보
대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.28 No.1
발행연도
2021.1
수록면
39 - 45 (7page)

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Background: In Korea, in the case of patients with significant bleeding symptoms due to unknown causes, there are very few studies that evaluate bleeding disorders, including von Willebrand disease (VWD). VWD should be considered as an important causative factor in patients with iron deficiency anemia (IDA) and unexplained menorrhagia. This study aimed to understand the clinical characteristics of VWD and the significance of evaluation for VWD in premenopausal women in Korea with menorrhagia and IDA. Methods: Premenopausal women who were diagnosed with IDA and menorrhagia from January 2009 to March 2020 were included. IDA was diagnosed by either low ferritin or transferrin saturation with microcytic anemia. Menorrhagia was evaluated based on the medical records obtained from a gynecologist. VWD diagnosis was defined as von Willebrand factor antigen ＜50% and von Willebrand factor ristocetin cofactor activity ＜50%, which were low according to the Hospital for Sick Children criteria. Results: Out of a total of 120 patients, only 12 were tested for VWD, all of whom were pediatric patients. Four of the 12 pediatric patients tested were diagnosed with VWD and 4 of the 120 (3.3%) patients with IDA and menorrhagia were diagnosed with VWD. Three out of the 4 patients was diagnosed with VWD by repeat screening test. Although all parameters are not statistically significant, VWD patients tended to have IDA at a younger age (13.25 vs. 15.00 years) and were more l ikely to have recurrent IDA than patients without VWD. Conclusion: Clinical doctors should consider VWD if patients have menorrhagia with IDA. I f VWD is suspected, repeated VWD screening tests are necessary to increase the diagnosis rate. Accurate diagnosis of VWD in patients with significant bleeding may facilitate decisions for appropriate treatment.
#von Willebrand disease #Anemia #Iron deficiency #Menorrhagia

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참고문헌 (26)

참고문헌 신청
Sharma R / 2017 / Advances in the diagnosis and treat-ment of von Willebrand disease / Hematology Am Soc Hematol Educ Program 2017:379~384 google schola Werner EJ / 1993 / Prevalence of von Willebrand disease in children : a mul-tiethnic study / J Pediatr 123:893~898 google schola Kadir RA / 2006 / Women and von Willebrand disease : con-troversies in diagnosis and management / Semin Thromb Hemost 32:605~615 google schola Ragni MV / 1999 / von Willebrand disease and bleeding in women / Haemophilia 5:313~317 google schola Chen YC / 2008 / Prevalence of von Willebrand disease in women with iron deficiency anaemia and menorrhagia in Taiwan / Haemophilia 14:768~774 google schola

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