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논문 기본 정보

자료유형
학술저널
저자정보
Amanpreet Sundh (All India Institute of Medical Sciences) Paramjit Kaur (Government Medical College and Hospital Chandigarh) Anshu Palta (Government Medical College and Hospital Chandigarh) Gagandeep Kaur (Government Medical College and Hospital Chandigarh)
저널정보
대한혈액학회 Blood Research Blood Research Vol.55 No.3
발행연도
2020.1
수록면
169 - 174 (6page)

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BackgroundThe aim of this study was to estimate the prevalence of the beta thalassemia trait (BTT) and differentiate it from iron-deficiency anemia (IDA) among blood donors.MethodsA total of 1,000 samples from blood donors were subjected to complete hemogram with red blood cell indices. Further, Mentzer index (MI) was calculated for samples with mean corpuscular volume (MCV) below 80 fL and mean corpuscular hemoglobin (MCH) below 27 pg. Samples with Mentzer index <12 were subjected to naked-eye single-tube red cell osmotic fragility test (NESTROFT) followed by hemoglobin electrophoresis in positive cases. Serum ferritin was assessed in NESTROFT-negative cases.ResultsThe prevalence of BTT among blood donors was 3.7% and that of microcytosis among donors was 8.6%. The prevalence of BTT among microcytic donors was 41.8% while that among those with IDA was 11.6%. A value of MI <13 was highly sensitive in the diagnosis of BTT. MI >13 was found to have both high specificity and high sensitivity for diagnosing IDA.ConclusionA moderately high prevalence of BTT was observed among blood donors. Presently, no screening program is mandatory for screening of BTT among blood donors. Indices like MCV, MCH, and Mentzer Index were thus found to be effective to screen for BTT and IDA among blood donors, and NESTROFT was a cost-effective mass screening method to differentiate BTT and IDA.

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